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Dissecting the role of microRNAs in effector versus regulatory CD4+ T cell diff...
Cunha, Carolina; Romero, Paula Vargas; Pelicano, Catarina; Pais, Ana Teresa; Inácio, Daniel; Papotto, Pedro; Amado, Tiago; Gomes, Anita Q.CD4+ T cells are key players in host defense against pathogens, but an incorrect balance between CD4+ T cell subsets, namely pro-inflammatory effector cells, including T helper 1 (Th)1 and Th17 cells (IFN-γ- and IL-17-producers, respectively), and anti-inflammatory regulatory cells (Treg; Foxp3+ subset), can lead to immune-mediated diseases. MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate ...
Date: 2021
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Origin: Repositório Científico do Instituto Politécnico de Lisboa