14 documents found, page 1 of 2
68Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake
Junqueira,Matheus Zanelatto; Rocha,Nelisa Helena; Sapienza,Marcelo TatitAbstract Objective: To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy. Materials and Methods: Ten patients with prostate cancer were submitted to 68Ga-PSMA positron emission tomogra...
Methods for quantification of cerebral glycolytic metabolism using 2-deoxy-2-[1...
Prando,Silvana; Ono,Carla Rachel; Robilotta,Cecil Chow; Sapienza,Marcelo TatitAbstract Introduction The use of the same imaging and quantification techniques in small animals and clinical studies presents the opportunity for direct translational research in drug discovery and development, in neuropharmacological basis of neurological and psychiatric diseases, and in optimization of drug therapy. Thus, positron emission tomography (PET) studies in rodents can bridge the gap between pre-cl...
Bone marrow uptake of 18F-fluorodeoxyglucose in Hodgkin lymphoma without bone i...
Vale,Rômulo Hermeto Bueno do; Ferraro,Daniela Andrade; Duarte,Paulo Schiavom; Carvalho,Giovana; Lima,Marcos Santos; Coura Filho,George BarbérioAbstract Objective: To compare the degree of benign bone marrow uptake of 18F-fluorodeoxyglucose (18F-FDG) between Hodgkin lymphoma patients with and without B symptoms. Materials and Methods: We analyzed the medical charts of 74 Hodgkin lymphoma patients who underwent 18F-FDG positron emission tomography/computed tomography (PET/CT) prior to the initiation of therapy between October 2010 and September 2013. In...
Receiver operating characteristic (ROC) curve for classification of18F-NaF upta...
Valadares,Agnes Araujo; Duarte,Paulo Schiavom; Carvalho,Giovanna; Ono,Carla Rachel; Coura-Filho,George Barberio; Sado,Heitor NaokiAbstract Objective: To assess the cutoff values established by ROC curves to classify18F-NaF uptake as normal or malignant. Materials and Methods: PET/CT images were acquired 1 hour after administration of 185 MBq of18F-NaF. Volumes of interest (VOIs) were drawn on three regions of the skeleton as follows: proximal right humerus diaphysis (HD), proximal right femoral diaphysis (FD) and first vertebral body (VB1...
Estimating 131I biokinetics and radiation doses to the red marrow and whole bod...
Willegaignon,José; Pelissoni,Rogério Alexandre; Lima,Beatriz Christine de Godoy Diniz; Sapienza,Marcelo Tatit; Coura-Filho,George BarberioAbstract Objective: To compare the probe detection method with the image quantification method when estimating 131I biokinetics and radiation doses to the red marrow and whole body in the treatment of thyroid cancer patients. Materials and Methods: Fourteen patients with metastatic thyroid cancer, without metastatic bone involvement, were submitted to therapy planning in order to tailor the therapeutic amount o...
Comparison of standardized uptake values measured on 18F-NaF PET/CT scans using...
Valadares,Agnes Araujo; Duarte,Paulo Schiavom; Woellner,Eduardo Bechtloff; Coura-Filho,George Barberio; Sapienza,Marcelo TatitObjective: To analyze standardized uptake values (SUVs) using three different tube current intensities for attenuation correction on 18FNaF PET/CT scans. Materials and Methods: A total of 254 18F-NaF PET/CT studies were analyzed using 10, 20 and 30 mAs. The SUVs were calculated in volumes of interest (VOIs) drawn on three skeletal regions, namely, right proximal humeral diaphysis (RH), right proximal femoral di...
Dose calibrator linearity test: 99mTc versus 18F radioisotopes
Willegaignon,José; Sapienza,Marcelo Tatit; Coura-Filho,George Barberio; Garcez,Alexandre Teles; Alves,Carlos Eduardo Gonzalez RibeiroObjective: The present study was aimed at evaluating the viability of replacing 18F with 99mTc in dose calibrator linearity testing. Materials and Methods: The test was performed with sources of 99mTc (62 GBq) and 18F (12 GBq) whose activities were measured up to values lower than 1 MBq. Ratios and deviations between experimental and theoretical 99mTc and 18F sources activities were calculated and subsequently ...
Prevalence of exclusive lower extremity metastases at 18F-NaF PET/CT
Ordones,Monique Beraldo; Valadares,Agnes Araujo; Duarte,Paulo Schiavom; Sado,Heitor Naoki; Lima,Marcos Santos; Carvalho,Giovanna; Sapienza,Marcelo TatitAbstractObjective:To evaluate the prevalence of exclusive lower extremity metastases, specifically in the femur and below the knee, observed at 18F-NaF PET/CT.Materials and Methods:One thousand consecutive PET/CT studies were retrospectively evaluated for the presence of exclusive uptake in lower extremities suggesting metastatic involvement. The presumptive diagnoses based on such uptakes were subsequently obt...
Accuracy of glomerular filtration rate estimation formulas for detecting modera...
Almeida,José Roberto de; Delfino,Vinicius Daher Alvares; Lima,Rejane Tavares de; Favero,Maria Emília; Sapienza,Marcelo Tatit; Matsuo,Tiemi<p><b>OBJECTIVE:</b> The objective of this study was to investigate the accuracy of a glomerular filtration rate (GFR) estimation equation based upon serum cystatin C (Hojs) and the abbreviated Modification of Diet in Renal Disease (MDRD) study and the Cockcroft-Gault (CG) corrected for body surface area (CG-BSA) estimation equations for detecting moderate chronic kidney disease against <sup>51</sup>Cr-EDTA cle...
Critérios semiquantitativos de análise da linfocintilografia em linfedema dos m...
Sapienza,Marcelo Tatit; Endo,Irene Shimura; Ferraro,Giselle Christina; Tavares,Márcia Garrido Modesto; Campos Neto,Guilherme de CarvalhoOBJETIVO: Avaliar se diferentes parâmetros de análise da linfocintilografia permitem a distinção entre membros com e sem linfedema em pacientes com quadro clínico de edema unilateral. MÉTODOS: Levantamento retrospectivo dos exames de 20 pacientes submetidos a linfocintilografia para investigação de edema unilateral de membros inferiores, divididos em pacientes com linfedema primário (grupo 1, n = 7) ou secundár...