2 documents found, page 1 of 1
Aptasensor for the detection of Moraxella catarrhalis adhesin UspA2
Sande, Maria; Ferreira, Débora; Rodrigues, Joana Lúcia Lima Correia; Melo, Luís Daniel Rodrigues; Saragliadis, Athanasios; Linke, DirkInnovative point-of-care (PoC) diagnostic platforms are desirable to surpass the deficiencies of conventional laboratory diagnostic methods for bacterial infections and to tackle the growing antimicrobial resistance crisis. In this study, a workflow was implemented, comprising the identification of new aptamers with high affinity for the ubiquitous surface protein A2 (UspA2) of the bacterial pathogen Moraxella ...
Design of new hydrolyzed collagen-modified magnetic nanoparticles to capture pa...
Sande, Maria Georgina; Roque, Lúcia; Braga, Adelaide Correia; Marques, Márcia; Ferreira, Débora Carina Gonçalves Abreu; Saragliadis, AthanasiosEnrichment and diagnosis tools for pathogens currently available are time consuming, thus the development of fast and highly sensitive alternatives is desirable. In this study, a novel approach was described that enables selective capture of bacteria expressing hydrolyzed collagen-binding adhesins with hydrolyzed collagen-coated magnetic nanoparticles (MNPs). This platform could be useful to shorten the time ne...