2 documents found, page 1 of 1
Liprobe, a vital dye for lipid aggregates detection in imaging and high-content...
Vieira, Sandra I.; Nunes da Silva, Raquel; Alves, Mariana; Dias, Roberto A.; Meireles Sousa, Ana M.; Camões, Fatima; Maia, André; Almeida, MónicaPathological lipid accumulation is a hallmark of several metabolic disorders, and detection of lipid aggregates is an essential step for initial diagnosis and drug screening purposes. However, low-cost, simple, and reliable detection fluorescent probes are not widely available. Here, six push-pull-push dyes were studied, and proved to be highly sensitive to the polarity of the medium, presenting potential to di...
Customizable and Regioselective One-Pot N−H Functionalization of DNA Nucleobase...
Rocha, Djenisa H. A; Machado, Carmen M.; Sousa, Vera; Sousa, Cristiana F. V.; Silva, Vera L. M.; Silva, Artur M.; Borges, João; Mano, João F.DNA is one of the most exciting biomolecules in nature for developing supramolecular biofunctional nanoarchitectures owing to the highly specific and selective interactions between complementary Watson-Crick base pairing. Herein, simple and one-pot synthetic procedures have been implemented for producing a library of DNA nucleobase derivatives endowed with reactive functional groups for bioconjugation and cross...