18 documents found, page 1 of 2
Molecular maps of synovial cells in inflammatory arthritis using an optimized s...
Edalat, Sam G.; Gerber, Reto; Houtman, Miranda; Lückgen, Janine; Teixeira, Rui Lourenço; Palacios Cisneros, Maria del Pilar; Pfanner, TamaraIn this study, we optimized the dissociation of synovial tissue biopsies for single-cell omics studies and created a single-cell atlas of human synovium in inflammatory arthritis. The optimized protocol allowed consistent isolation of highly viable cells from tiny fresh synovial biopsies, minimizing the synovial biopsy drop-out rate. The synovium scRNA-seq atlas contained over 100,000 unsorted synovial cells fr...
Frameworks de gamificação enquadrados numa visão sistémica: uma revisão
Saraiva, FernandoO presente artigo faz uma revisão focada sobre frameworks de Gamificação que podem ser enquadradas numa visão sistémica, no âmbito dos sistemas de informação. Gamificação é o uso de elementos derivados dos jogos em contextos que não são jogos. Nesse sentido, foi proposta uma terminologia que possa ser usada em várias implementações e cenários. É discutida a forma como a terminologia proposta está alinhada com o...
Ultrasound-guided synovial biopsy : a review
Saraiva, FernandoUltrasound-guided synovial biopsy is a safe, well-tolerated, and effective method to collect good-quality synovial tissue from all types of joints for clinical and research purposes. Although synovial biopsy cannot be used to distinguish between types of inflammatory rheumatic disease, analysis of synovial tissue has led to remarkable advances in the understanding of the pathobiology of rheumatoid arthritis and...
Ultrasound halo sign as a potential monitoring tool for patients with giant cel...
Ponte, Cristina; Monti, Sara; Scirè, Carlo Alberto; Delvino, Paolo; Khmelinskii, Nikita; Milanesi, Alessandra; Teixeira, Vítor; Brandolino, FabioObjectives: To assess the sensitivity to change of ultrasound halo features and their association with disease activity and glucocorticoid (GC) treatment in patients with newly diagnosed giant cell arteritis (GCA). Methods: Prospective study of patients with ultrasound-confirmed GCA who underwent serial ultrasound assessments of the temporal artery (TA) and axillary artery (AX) at fixed time points. The number ...
Efficacy, safety, and sample quality of ultrasound‐guided synovial needle biops...
Romão, Vasco C.; Polido Pereira, Joaquim; Barros, Rita; Luis, Rita; Vidal, Bruno; Vieira De Sousa, Elsa Cristina; Vitorino, Emília; Humby, FrancesObjective: To study the efficacy, tolerability, safety, and sampling variation of ultrasound (US)-guided synovial biopsies performed in clinical practice and research. Methods: We included all patients who had a US-guided synovial needle biopsy from November 2013 to January 2018. Patients were evaluated for procedure safety and tolerability. Usefulness of synovial biopsy was considered based on contribution for...
Rheumatology practice amidst the COVID-19 pandemic : a pragmatic view
Romão, Vasco C.; Cordeiro, Inês; Macieira, Carla; Oliveira-Ramos, Filipa; Romeu, José; Rosa, Carlos Miranda; Saavedra, Maria João; Saraiva, FernandoThe coronavirus disease 2019 (COVID-19) pandemic has come with many challenges for healthcare providers and patients alike. In addition to the direct burden it has placed on societies and health systems, it had a significant impact in the care of patients with chronic diseases, as healthcare resources were deployed to fight the crisis, and major travel and social restrictions were adopted. In the field of rheum...
Building a virtual community of practice of researchers in Open and Distance Le...
Morgado, Lina; Rocha, Maria Antonieta; Seco, Carlos; Saraiva, Fernando; Oliveira, Nuno RicardoThis article describes a study focused on a group of researchers from a Portuguese Higher ducation Research Center (R&DU). We wanted to see if these researchers considered themselves a community of learning, of practice, or of any type, emerging from the use of virtual environments. We conducted an exploratory qualitative study, integrated in a broader research. We started by making a reflection on the concepts...
Gamification with gifts and emotional presence
Saraiva, FernandoThe study wants to see the impact of gamification on emotional presence of a community of inquiry, of teachers and students. A social platform based on elgg will be developed, with gamification elements like virtual currency and gifts. The platform will have tools to support the co-creation of content with the “affinity space” perspective in mind. We will use a mixed-methods approach, gathering data from the an...
Portuguese recommendations for the use of ultrasound in rheumatology
Polido Pereira, Joaquim; Serra, Sara; Teixeira, Filipa; Ponte, Cristina; Cerqueira, Marcos; Cruz, Margarida; Araújo, Filipe; Barros, Rita; Costa, TiagoIntroduction: Ultrasound (US) is a relatively cheap, easily available and reliable method to improve the care of rheumatic patients. However, its use in rheumatology practice is very heterogeneous and needs to be standardized. Objectives: To develop recommendations for the use of US in rheumatic diseases endorsed by the Portuguese Society of Rheumatology. Methods: A systematic literature review of the available...
Virtual communities of practice in distance education: An exploratory study for...
Morgado, Lina; Rocha, Antonieta; Seco, Carlos; Saraiva, Fernando; Oliveira, Nuno RicardoAs part of the online experience of researchers from a Portuguese Higher Education Research Center, there was a need to ascertain whether these researchers consider themselves within a community of practice, learning, or other community emerging from virtual environments. An exploratory study of a qualitative nature was conducted, based on a semi-structured interview with a limited peer group, in order to creat...