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Impacto do fumo do cigarro passivo no proteoma humano: em busca de biomarcadore...
Neves, Sofia; Pacheco, Solange A.; Vaz, Fátima; Valentim-Coelho, Cristina; Saraiva, Joana; James, Peter; Simões, Tânia; Penque, DeborahOs não-fumadores expostos ao fumo do cigarro passivo ou, simplesmente fumo passivo (FP), apresentam um risco acrescido de desenvolver diversas doenças graves. No entanto, os mecanismos moleculares que explicam estes efeitos continuam pouco esclarecidos, o que reforça a necessidade de identificar biomarcadores capazes de avaliar o risco associado a esta exposição. Neste estudo, analisámos o proteoma do epitélio ...
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osório, Hugo; Antunes, Marília; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahObstructive Sleep Apnea (OSA) is characterized by recurrent-episodes of apneas/hypopneas during sleep, leading to recurrent intermittent-hypoxia and sleep fragmentation. Non-treated OSA can result in cardiometabolic diseases. In this study, we applied a shotgun-proteomics strategy to deeper investigate the red blood cell-(RBC) homeostasis regulation in the context of OSA-severity and their response to six month...
Second-hand smoke exposure modulates plasma proteins linked to detoxification, ...
Neves, Sofia; Pacheco, Solange A.; Vaz, Fátima; Valentim-Coelho, Cristina; Saraiva, Joana; James, Peter; Simões, Tânia; Penque, DeborahChronic exposure to second-hand smoke (SHS) contributes to the development of health issues, including cancer and cardiovascular diseases. Molecular mechanisms underlying SHS-related diseases remain poorly understood, highlighting the need for reliable risk assessment biomarkers. Herein, we demonstrate that the plasma proteome of individuals exposed to SHS undergoes significant modulation. Butyrylcholinesterase...
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osorio, Hugo; Antunes, Marília; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahFunding Information: Project partially supported by Harvard Medical School \u2013 Portugal Program ( HMSPICJ/0022/2011 ), Instituto Nacional de Sa\u00FAde Dr. Ricardo Jorge \u2013 INSA, Centro de Toxicogen\u00F3mica e Sa\u00FAde Humana \u2013 ToxOmics, Rede Nacional de Espectrometria de Massa \u2013 RNEM, FCT /Poly-Annual Funding Program and FEDER /Sa\u00FAde XXI Program, Portugal. Cristina Coelho (SFRH/BD/1335...
Second-hand smoke exposure modulates plasma proteins linked to detoxification, ...
Neves, Sofia; Pacheco, Solange A.; Vaz, Fátima; Valentim-Coelho, Cristina; Saraiva, Joana; James, Peter; Simões, Tânia; Penque, DeborahFunding Information: This work was supported by the Calouste Gulbenkian Foundation, Rede Nacional de Espectrometria de Massa (RNEM), National Institute of Health Doctor Ricardo Jorge, and UID/04923 - Comprehensive Health Research Centre.Sofia Neves (SFRH/BD/82648/2011), Solange A. Pacheco (SFRH/BD/74857/2010), Cristina Valentim-Coelho (SFRH/BD/133511/2017) and Joana Saraiva (2022.14435.BD) were granted with PhD...
Discriminative Protein Markers of Second-Hand Smoke Exposure Identified by Shot...
Neves, Sofia; Pacheco, Solange A.; Vaz, Fátima; Saraiva, Joana; James, Peter; Simões, Tânia; Penque, DeborahObjective: Chronic exposure to second-hand smoke (SHS) increases the risk of developing tobacco-related pathologies such as lung cancer and cardiovascular diseases. This study aimed to identify potential protein biomarkers for response and risk assessment of SHS exposure. Methods: A shotgun proteomics approach was employed to analyse protein expression profiles in nasal epithelium and plasma samples from health...
Red blood cell proteomic profiling in mild and severe obstructive sleep apnea p...
Valentim-Coelho, Cristina; Saraiva, Joana; Osório, Hugo; Antunes, Marilia; Vaz, Fátima; Neves, Sofia; Pinto, Paula; Bárbara, Cristina; Penque, DeborahObstructive Sleep Apnea (OSA) is characterized by recurrent-episodes of apneas/hypopneas during sleep, leading to recurrent intermittent-hypoxia and sleep fragmentation. Non-treated OSA can result in cardiometabolic diseases. In this study, we applied a shotgun-proteomics strategy to deeper investigate the red blood cell-(RBC) homeostasis regulation in the context of OSA-severity and their response to six month...
Multiomics screening of red blood cells (RBCs) reveals new candidate diagnostic...
Febra, Cláudia; Saraiva, Joana; AlKhnbashi, Omer; Pinto, Frederico G.; Vaz, Fátima; Macedo, João; Uddin, Mohammed J.; Goswami, Nandu; Penque, DeborahVenous Thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is still based on complex imaging exams due to the lack of biomarkers. However, studies assessing the diagnostic capacity of novel biomarkers in VTE are scarce. We aimed to determine if patients with acute VTE have differences in the proteomics/metabolomic profile. This observational trial included 62 patient...
Multiomics profiling of Red Blood Cells (RBCs) combined with Deep Machine Learn...
Febra, Cláudia; Saraiva, Joana; AlKhnbashi, Omer; Vaz, Fátima; Macedo, João; Uddin, Mohammed J.; Penque, Deborah; Soares, Nelson C.Background and aims: Venous Thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is still based on complex imaging exams due to the lack of biomarkers. However, studies assessing the diagnostic capacity of novel metabolomics biomarkers in VTE are scarce. Our aim was to determine whether patients with acute VTE exhibit differences in proteomic and metabolomic profiles.
Acute venous thromboembolism plasma and red blood cell metabolomic profiling re...
Febra, Claúdia; Saraiva, Joana; Vaz, Fátima; Soares, Nelson; Penque, PenqueBackground: Venous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams due to the lack of biomarkers. Recent multi-omics based research has contributed to the development of novel biomarkers in cardiovascular diseases. Our aim was to determine whether patients with acute VTE have differences in the metabolomic profile compared to non...