6 documents found, page 1 of 1
Delivery of an anti-transthyretin Nanobody to the brain through intranasal admi...
Gomes, JR; Cabrito, I; Soares, H; Costelha, S; Teixeira, A; Wittelsberger, A; Stortelers, C; Vanlandschoot, P; Saraiva, MJTransthyretin (TTR) is a transport protein of retinol and thyroxine in serum and CSF, which is mainly secreted by liver and choroid plexus, and in smaller amounts in other cells throughout the body. The exact role of TTR and its specific expression in Central Nervous System (CNS) remains understudied. We investigated TTR expression and metabolism in CNS, through the intranasal and intracerebroventricular delive...
BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective...
Lopes, CDF; Gonçalves, NP; Gomes, CP; Saraiva, MJ; Pêgo, APNeuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimally invasive intramuscular administration. Nanoparticles were grafted with the non-toxic carboxylic fragment of the tetanus neurotoxin (HC) to al...
BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective...
Lopes, C; Gonçalves, N; Gomes, C; Saraiva, MJ; Pêgo, APNeuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimally invasive intramuscular administration. Nanoparticles were grafted with the non-toxic carboxylic fragment of the tetanus neurotoxin (HC) to al...
Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin a...
Ferreira, N; Gonçalves, NP; Saraiva, MJ; Almeida, MTransthyretin amyloidoses encompass a variety of acquired and hereditary diseases triggered by systemic extracellular accumulation of toxic transthyretinaggregates and fibrils, particularly in the peripheral nervous system. Since transthyretin amyloidoses are typically complex progressive disorders, therapeutic approaches aiming multiple molecular targets simultaneously, might improve therapy efficacy and treat...
Transthyretin participates in beta-amyloid transport from the brain to the live...
Alemi, M; Gaiteiro, C; Ribeiro, C; Santos, L; Gomes, J; Oliveira, S; Couraud, P; Weksler, B; Romero, I; Saraiva, MJ; Cardoso, ITransthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is decreased in Alzheimer’s disease (AD) patients. Additionally, AD transgenic mice with only one copy of the TTR gene show increased brain and plasma Aβ levels when compared to AD mice with both copies of the gene, suggesting TTR involvement in brain Aβ efflux and/or peripheral clearance. Here we showed that TTR promotes Aβ inter...
Deposition and passage of transthyretin through the blood-nerve barrier in reci...
Sousa, MM; Ferrão, J; Fernandes, R; Guimarães, A; Geraldes, B; Perdigoto, R; Tomé, L; Mota, O; Negrão, L; Furtado, AL; Saraiva, MJFamilial amyloid polyneuropathy (FAP) is characterized by deposition of mutated transthyretin (TTR) in the peripheral nervous system. Prior to amyloid fibrils, nonfibrillar TTR aggregates are deposited inducing oxidative stress with increased nitration (3-NT). As the major source of TTR is the liver, liver transplantation (LT) is used to halt FAP. Given the shortage of liver donors, domino LT (DLT) using FAP li...