6 documents found, page 1 of 1
Posttranslational modifications of proteins are key features in the identificat...
Salazar, Ivan L.; Lourenço, Ana S. T.; Manadas, Bruno; Baldeiras, Inês; Ferreira, Cláudia; Teixeira, Anabela Claro; Mendes, Vera M.; Novo, Ana MargaridaMultiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory diseases of the central nervous system, makes it difficult to have a clear diagnosis of multiple sclerosis. Therefore, laboratory tests that allows a clear and definite diagnosis...
In vitro and in vivo effects of SerpinA1 on the modulation of Transthyretin pro...
Bezerra, Filipa; Niemietz, Christoph; Schmidt, Hartmut H. J.; Zibert, Andree; Guo, Shuling; Monia, Brett P.; Gonçalves, Paula Isabel MeiraTransthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of both cleaved and full-length TTR, particularly in the heart. The fragmentation pattern at Lys48 suggests the involvement of a serine protease, such as plasmin. The mos...
Effects of transthyretin stabilization by wine polyphenols in the modulation of...
Rodrigues, Daniela; Santos, Luís M.; Alemi, Mobina; Ribeiro, Carlos; Saraiva, Maria João; Mateus, Nuno; Cardoso, IsabelAlzheimer’s disease (AD) is the most common type of dementia, accounting for 60% to 80% of all cases worldwide. Senile plaques, one of AD hallmarks, are mainly constituted of A peptide. Transthyretin (TTR) has been described to exert a neuroprotective effect in AD by interacting with A. This activity is dependent on its stability, thus compounds that stabilize TTR tetrameric fold increase TTR/A binding. Most of...
Stability of the transthyretin molecule as a key factor in the interaction with...
Ribeiro, Carlos A.; Saraiva, Maria João; Cardoso, IsabelTransthyretin (TTR) protects against A-Beta toxicity by binding the peptide thus inhibiting its aggregation. Previous work showed different TTR mutations interact differently with A-Beta, with increasing affinities correlating with decreasing amyloidogenecity of the TTR mutant; this did not impact on the levels of inhibition of A-Beta aggregation, as assessed by transmission electron microscopy. Our work aimed ...
Transthyretin and Alzheimer's disease: where in the brain?
Sousa, João Carlos; Cardoso, Isabel; Marques, Fernanda; Saraiva, Maria João; Palha, Joana AlmeidaTransthyretin (TTR), a carrier protein for thyroxine and retinol in plasma and cerebrospinal fluid (CSF), has been shown to bind the amyloid beta peptide. Accordingly, TTR has been suggested to protect against amyloid beta deposition, a key pathological feature in Alzheimer's disease (AD). Supporting this view are the reduced TTR levels found in CSF of patients with AD, as well as reports of altered TTR express...
Transthyretin is involved in depression-like behaviour and exploratory activity
Sousa, João Carlos; Grandela, Catarina; Fernández-Ruiz, Javier; Miguel, Rosário de; Sousa, Liliana de; Magalhães, Ana Isabel; Saraiva, Maria JoãoTransthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer β-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the per...