8 documents found, page 1 of 1
Revisiting thyroid hormones in schizophrenia
Santos, Nadine Correia; Costa, Patrício; Ruano, Dina; Macedo, António; Soares, Maria João; Valente, José; Pereira, Ana Telma; Azevedo, Maria HelenaThyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosign...
Revisiting thyroid hormones in schizophrenia
Santos, Nadine Correia; Costa, Patrício Soares; Ruano, Dina; Macedo, António; Soares, Maria João; Valente, José; Pereira, Ana TelmaThyroid hormones are crucial during development and in the adult brain. Of interest, fluctuations in the levels of thyroid hormones at various times during development and throughout life can impact on psychiatric disease manifestation and response to treatment. Here we review research on thyroid function assessment in schizophrenia, relating interrelations between the pituitary-thyroid axis and major neurosign...
Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degene...
Rollinson, Sara; Rizzu, Patrizia; Sikkink, Stephen; Baker, Matthew; Halliwell, Nicola; Snowden, Julie; Traynor, Bryan J.; Ruano, Dina; Cairns, Nigelhttp://www.sciencedirect.com/science/article/B6T09-4VKMW0R-1/2/c38ac7e3dcb87f1e42d35a151a3f69b2
Transthyretin: No association between serum levels or gene variants and schizop...
Ruano, Dina; Macedo, António; Soares, Maria J.; Valente, José; Azevedo, Maria H.; Hutz, Mara H.; Gama, Clarissa S.; Lobato, Maria I.It has been proposed that schizophrenia results from an environmental insult in genetically predisposed individuals. Environmental factors capable of modulating transcriptional activity and their carriers could link the genetic and environmental components of schizophrenia. Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP). Retinoids and thyroid hormones r...
Family-based and case-control studies reveal no association of lipocalin-type p...
Ruano, Dina; Macedo, António; Soares, Maria João; Valente, José; Azevedo, Maria Helena; Pato, Carlos; Hutz, Mara Helena; Gama, Clarissa S.Several observations point to the involvement of disturbed lipid biology in schizophrenia. Reduced response to niacin flushing test, which involves vasodilatation induced by prostaglandin D2 (PGD2), is among the evidences, together with decreased CSF levels of lipocalin-type prostaglandin D2 synthase (PTGDS), the enzyme responsible for the synthesis of PGD2 in the brain. Since PTGDS is also a carrier for lipoph...
Transthyretin: no association between serum levels or gene variants and schizop...
Ruano, Dina; Macedo, António; Soares, Maria J.; Valente, José; Azevedo, Maria H.; Hutz, Mara H.; Gama, Clarissa S.; Lobato, Maria I.It has been proposed that schizophrenia results from an environmental insult in genetically predisposed individuals. Environmental factors capable of modulating transcriptional activity and their carriers could link the genetic and environmental components of schizophrenia. Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP). Retinoids and thyroid hormones r...
NR4A2 and schizophrenia: Lack of association in a Portuguese/Brazilian study
Ruano, Dina; Macedo, António; Dourado, Ana; Soares, Maria João; Valente, José; Coelho, Isabel; Santos, Vítor; Azevedo, Maria Helena; Goodman, AnnThe present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients. The human Nur-related receptor 1, NR4A2, is an orphan nuclear receptor that can be constitutively active as a transcription factor and for which no natural ligand has yet been identified. Alone or with retinoid X receptor, RXR, NR4A2 influences the expression of several genes important for human ...
NR4A2 and schizophrenia: lack of association in a portuguese/brazilian study
Ruano, Dina; Macedo, António; Dourado, Ana; Soares, Maria João; Valente, José; Coelho, Isabel; Santos, Vítor; Azevedo, Maria Helena; Goodman, AnnThe present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients. The human Nur-related receptor 1, NR4A2, is an orphan nuclear receptor that can be constitutively active as a transcription factor and for which no natural ligand has yet been identified. Alone or with retinoid X receptor, RXR, NR4A2 influences the expression of several genes important for human ...