5 documents found, page 1 of 1
Dynamic Combinatorial Chemistry Unveils Nsp10 Inhibitors with Antiviral Potenti...
Jumde, Ravindra P.; Jézéquel, Gwenaëlle; Saramago, Margarida; Frank, Nicolas; Adam, Sebastian; Cunha, Marta V.; Bader, Chantal D.; Gunesch, Antonia P.Funding Information: Work at ITQB NOVA was supported by FCT \u2013 Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, I.P., through MOSTMICRO-ITQB R&D Unit (UIDB/04612/2020, UIDP/04612/2020) and LS4FUTURE Associated Laboratory (LA/P/0087/2020). It was also funded by project PTDC/BIA-BQM/28479/2017 from FCT to RGM. MS was financed by an FCT contract according to DL57/2016, [SFRH/BPD/109464/2015], RGM by an F...
SARS-CoV2 Nsp1 is a metal-dependent DNA and RNA endonuclease
Salgueiro, Bruno A.; Saramago, Margarida; Tully, Mark D.; Issoglio, Federico; Silva, Sara T.N.; Paiva, Ana C.F.; Arraiano, Cecília M.; Matias, Pedro M.Funding Information: Open access funding provided by FCT|FCCN (b-on). This study was financially supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT), Project MOSTMICRO-ITQB with references UIDB/04612/2020 and UIDP/04612/2020, iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), and LS4FUTURE Associated Laboratory (LA/P/0087/2020). BAS is recipient of FCT PhD4COVID grant SFRH/BD/08066/2020; RGM...
A Comparative Overview of the Role of Human Ribonucleases in Nonsense-Mediated ...
da Costa, Paulo J.; Menezes, Juliane; Guedes, Raquel; Reis, Filipa P.; Teixeira, Alexandre; Saramago, Margarida; Viegas, Sandra C.; Arraiano, Cecília M.Funding Information: This work was partially supported by Instituto Nacional de Sa\u00FAde Doutor Ricardo Jorge and Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT), Portugal [UIDB/04046/2020 (DOI: 10.54499/UIDB/04046/2020), and UIDP/04046/2020 (https://doi.org/10.54499/UIDP/04046/2020) Centre grants from FCT (to BioISI)]. P.J.d.C. was recipient of a fellowship from the BioSys PhD programme (SFRH/BD/...
Tailor-made sRNAs
Apura, Patrícia; Saramago, Margarida; Peregrina, Alexandra; Viegas, Sandra C.; Carvalho, Sandra M.; Saraiva, Lígia M.; Arraiano, Cecília M.Pseudomonas putida is a highly attractive production system for industrial needs. However, for its improvement as a biocatalyst at the industrial level, modulation of its gene expression is urgently needed. We report the construction of a plasmid expressing a small RNA-based system with the potential to be used for different purposes. Due to the small RNAs modular composition, the design facilities and ability ...
Experimental supporting data on DIS3L2 over nonsense-mediated mRNA decay target...
da Costa, Paulo J.; Menezes, Juliane; Saramago, Margarida; García-Moreno, Juan F.; Santos, Hugo A.; Gama-Carvalho, Margarida; Arraiano, Cecília M.In this article, we present supportive data related to the research article “A role for DIS3L2 over natural nonsense-mediated mRNA decay targets in human cells” [1], where interpretation of the data presented here is available. Indeed, here we analyze the impact of the DIS3L2 exoribonuclease over nonsense-mediated mRNA decay (NMD)-targets. Specifically, we present data on: a) the expression of various reporter ...