2 documents found, page 1 of 1
Biological markers of Alzheimer?s disease
Souza,Leonardo Cruz de; Sarazin,Marie; Teixeira Júnior,Antônio Lúcio; Caramelli,Paulo; Santos,Antônio Emanuel dos; Dubois,BrunoThe challenges for establishing an early diagnosis of Alzheimer’s disease (AD) have created a need for biomarkers that reflect the core pathology of the disease. The cerebrospinal fluid (CSF) levels of total Tau (T-tau), phosphorylated Tau (P-Tau) and beta-amyloid peptide (Aβ42) reflect, respectively, neurofibrillary tangle and amyloid pathologies and are considered as surrogate markers of AD pathophysiology. T...
Frontal presentation of Alzheimer's disease: A series of patients with biologic...
Souza,Leonardo Cruz de; Bertoux,Maxime; Funkiewiez,Aurélie; Samri,Dalila; Azuar,Carole; Habert,Marie-Odile; Kas,Aurélie; Lamari,Foudil; Sarazin,MarieABSTRACT Besides its typical amnesic presentation, focal atypical presentations of Alzheimer's disease (AD) have been described in neuropathological studies. These phenotypical variants of AD (so-called "atypical AD") do not follow the typical amnestic pattern and include non-amnestic focal cortical syndromes, such as posterior cortical atrophy and frontal variant AD. These variants exhibit characteristic histo...