4 documents found, page 1 of 1
Fostering conservancy through bioprospection: the pharmaceutical value of the b...
Sahm, Bianca Del Bianco; Guimarães, Larissa Alves; Wilke, Diego Veras; Bauermeister, Anelize; Costa-Lotufo, Leticia Veras; Jimenez, Paula C.The inherent value of nature is immeasurable. That being said, through bioprospection – the systematic search for functional products or processes from living organisms –, the oceans and marine life have emerged as a relevant source of biodiscoveries that hold significant economic worth. Particularly considering the pharmaceutical industry, an increasing number of natural molecules of marine origin have been ma...
Estudos alvo-direcionados de produtos naturais de actinobactérias marinhas
Guimarães, Larissa AlvesThe development of different strategies for prospecting natural products which have the molecular target as the key perspective has contributed to innovation and discovery of new substances with anticancer potential. In this context, this work carried out the study of natural products from marine actinobacteria through different approaches for the elucidation of the molecular target of action of the isolated su...
Potencial anticâncer de actinomicetos recuperados do sedimento da praia da Pedr...
Guimarães, Larissa AlvesThe sea sediment is an important source of microorganisms that synthesize secondary metabolites with biomedical proprieties. During the past 10 years, the coast of Ceará has been prospected for the pharmacological potential housed in sponges, tunicates and corals, but little data are available regarding that of the microorganisms. In the present study, crude extracts from actinomycetes recovered from sediment c...
Chromomycin A2 induces autophagy in melanoma cells
Guimarães, Larissa Alves; Jimenez, Paula Christine; Sousa, Thiciana da Silva; Freitas, Hozana Patrícia S.; Rocha, Danilo Damasceno; Wilke, Diego VerasThe present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp., recovered from Paracuru Beach, located in the northeast region of Brazil. The cytotoxic activity of chromomycin A2 was evaluated across a panel of human tumor cell ...