26 documents found, page 1 of 3
Chemical Characterization and Differential Lipid-Modulating Effects of Selected...
Amorim, Ricardo; Marques, Mário Pedro; Melim, Catarina; Varela, Carla; Sardão, Vilma A.; Teixeira, José; Dias, Maria Inês; Barros, LillianCôa Valley, located in the northeast of Portugal, harbors more than 500 medicinal plant species. Among them, four species stand out due to their traditional uses: Equisetum ramosissimum Desf. (hemorrhages, urethritis, hepatitis), Rumex scutatus L. subsp. induratus (Boiss. and Reut.) Malag. (inflammation, constipation), Geranium purpureum Vill., and Geranium lucidum L. (pain relief, gastric issues). Given their ...
Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolys...
Bessa, Cláudia; Loureiro, Joana B.; Barros, Matilde; Isca, Vera M. S.; Sardão, Vilma A.; Oliveira, Paulo J.; Bernardino, Raquel L.Metabolic reprogramming is a central hub in tumor development and progression. Therefore, several efforts have been developed to find improved therapeutic approaches targeting cancer cell metabolism. Recently, we identified the 7a-acetoxy-6b-benzoyloxy-12-O-benzoylroyleanone (Roy- Bz) as a PKC -selective activator with potent anti-proliferative activity in colon cancer by stimulating a PKC -dependent mitochondr...
Brassica oleracea Var italica by-Products Prevent Lipid Accumulation and Cell D...
Castelão-Baptista, José P.; Valente, Sara A.; Canário, Sara; Oppolzer, David; Barros, Ana; Venâncio, Carlos; Martins, Tânia; Antunes, LuísObesity, a rising concern in the Eastern world, encompasses several co-morbidities, namely non-alcoholic fatty liver disease (NAFLD). Potential natural-based interventions to decrease the burden of obesity complications are being investigated. Many of the edible parts of plants are not sold for consumption and end up as massive waste, losing nutritional potential. In fact, a sizeable amount of waste is generate...
ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts...
Carvalho, Adriana Marques; Sardão, Vilma A.; Kim, Ha-Neui; Almeida, Maria SIntroduction: Estrogens inhibit bone resorption and preserve bone mass, at least in part, via direct effects on osteoclasts. The binding of RANKL, the critical cytokine for osteoclast differentiation, to its receptor in osteoclast precursor cells of the monocyte lineage recruits the adaptor protein TRAF6 and activates multiple signaling pathways. Early effects of RANKL include stimulation of mitochondria. 17b-e...
The Impact of Moderate-to-High-Intensity Exercise Protocols on Glycated Hemoglo...
Pedrosa, Ana; Furtado, Guilherme E.; de Barros, Marcelo Paes; Bachi, André Luís Lacerda; Ferreira, José Pedro; Sardão, Vilma A.; Rama, LuísType 2 diabetes mellitus (T2DM) is a growing global health issue that is closely linked to the epidemic of obesity. In addition to genetic factors, environmental and health-risk behaviours (i.e., high-carbohydrate diet and physical inactivity) contribute to a variety of pathophysiological disorders. Advanced exercise protocols, such as Moderate-to-intensity (MIT) and High Intensity Interval Training (HIIT), rev...
Three in One: The Potential of Brassica By-Products against Economic Waste, Env...
Castelão-Baptista, José P.; Barros, Ana; Martins, Tânia; Rosa, Eduardo; Sardão, Vilma A.A large amount of waste is generated within the different steps of the food supply chain, representing a significant loss of natural resources, plant material, and economic value for producers and consumers. During harvesting and processing, many parts of edible plants are not sold for consumption and end up as massive waste, adding environmental hazards to the list of concerns regarding food wastage. Examples ...
Afrostyrax lepidophyllus Mildbr. and Monodora myristica (Gaertn.) Dunal Extract...
Moukette, Bruno; Castelão-Baptista, José P.; Ferreira, Luciana L.; Silva, Ana M.; Simões, Rui F.; Cabral, Célia; Pieme, Constant A.; Ngogang, Jeanne Y.Ethnopharmacological Relevance. Doxorubicin (Dox) is an anthracycline antibiotic widely used in cancer treatment. Despite its antitumor efficacy, its clinical application is significantly limited because of its cardiotoxicity originated, among other factors, from pro-oxidant damage to cardiac mitochondria. Phytochemicals represent a potentially attractive strategy to mitigate Dox cardiotoxicity due to their ant...
Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine
Bento, Guida; Shafigullina, Aygul K.; Rizvanov, Albert A.; Sardão, Vilma A.; Macedo, Maria Paula; Oliveira, Paulo J.Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem ...
Estrogens decrease osteoclast number by attenuating mitochondria oxidative phos...
Kim, Ha-Neui; Ponte, Filipa; Nookaew, Intawat; Ucer Ozgurel, Serra; Carvalho, Adriana Marques; Iyer, Srividhya; Warren, Aaron; Aykin-Burns, NukhetLoss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. Here, we investigated the molecular mechanism of this effect. We report that 17β-estradiol (E2) decreased osteoclast number by promoting the apoptosis of early osteoclast progenitors, but not matur...
A Mitochondrial Approach to Cardiovascular Risk and Disease
Veloso, Caroline D.; Belew, Getachew D.; Ferreira, Luciana L.; Grilo, Luís F.; Jones, John Griffith; Portincasa, Piero; Sardão, Vilma A.Cardiovascular diseases (CVDs) are a leading risk factor for mortality worldwide and the number of CVDs victims is predicted to rise through 2030. While several external parameters (genetic, behavioral, environmental and physiological) contribute to cardiovascular morbidity and mortality; intrinsic metabolic and functional determinants such as insulin resistance, hyperglycemia, inflammation, high blood pressure...