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Exposure to Obesogenic Environments during Perinatal Development Modulates Offs...
Sousa, Diana; Sá-Rocha, Mariana; Amaro, Andreia; Ferreira-Junior, Marcos Divino; Cavalcante, Keilah Valéria Naves; Monteiro-Alfredo, TamaehObesogenic environments such as Westernized diets, overnutrition, and exposure to glycation during gestation and lactation can alter peripheral neuroendocrine factors in offspring, predisposing for metabolic diseases in adulthood. Thus, we hypothesized that exposure to obesogenic environments during the perinatal period reprograms offspring energy balance mechanisms. Four rat obesogenic models were studied: mat...
Postnatal Overfeeding in Rodents Induces a Neurodevelopment Delay and Anxious-l...
Amaro, Andreia; Sousa, Diana Isabel Teixeira de; Sá-Rocha, Mariana; Ferreira-Junior, Marcos Divino; Rosendo-Silva, DanielaNutritional disturbances during the early postnatal period can have long-lasting effects on neurodevelopment and may be related to behavioural changes at adulthood. While such neuronal connection disruption can contribute to social and behaviour alterations, the dysregulation of the neuroendocrine pathways involved in nutrient-sensing balance may also cause such impairments, although the underlying mechanisms a...
COVID-19 During Development: A Matter of Concern
Saavedra, Lucas Paulo Jacinto; Prates, Kelly Valério; Gonçalves, Gessica Dutra; Piovan, Silvano; Matafome, Paulo N.; Mathias, Paulo Cezar de FreitasA new infectious disease, COVID-19, has spread around the world. The most common symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are cough and fever, but severe cases can develop acute respiratory distress syndrome. The main receptor for SARS-CoV-2 in human tissue is angiotensin-converting enzyme 2, and the lungs, heart, and kidneys are the most affected organs. Besides the in...