2 documents found, page 1 of 1
Left-right side-specific endocrine signaling complements neural pathways to med...
Lukoyanov, NV; Watanabe, H; Carvalho, LS; Kononenko, O; Sarkisyan, D; Zhang, M; Andersen, MS; Lukoyanova, EA; Galatenko, V; Tonevitsky, A; Bazov, IBrain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expr...
Left-right side-specific neuropeptide mechanism mediates contralateral response...
Watanabe, H; Nosova, O; Sarkisyan, D; Andersen, MS; Carvalho, LS; Galatenko, V; Bazov, I; Lukoyanov, NV; Maia, GH; Hallberg, M; Zhang, M; Schouenborg, JNeuropeptides are implicated in control of lateralized processes in the brain. A unilateral brain injury (UBI) causes the contralesional sensorimotor deficits. To examine whether opioid neuropeptides mediate UBI induced asymmetric processes we compared effects of opioid antagonists on the contralesional and ipsile-sional hindlimb responses to the left-sided and right-sided injury in rats. UBI induced hindlimb p...