38 documents found, page 1 of 4
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-v...
Reina-Couto, M; Alves, D; Silva-Pereira, C; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Dias, CC; Sarmento, A"Background and aims: Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane oxygenation (VV-ECMO), hypertension or previous renin-angiotensin-aldosterone system (RAAS) inhibitors treatment. We compared endocan and other endotheliitis markers in hospitalized COVID-19 patients and assessed their modulation by VV-ECMO, hypertension and previous R...
Evaluation of urinary cysteinyl leukotrienes as biomarkers of severity and puta...
Reina-Couto, M; Roboredo-Madeira, M; Pereira-Terra, P; Silva-Pereira, C; Martins, S; Teixeira-Santos, L; Pinho, D; Dias, A; Cordeiro, G; Dias, CCBackground Cysteinyl leukotrienes (CysLT) are potent inflammation-promoting mediators, but remain scarcely explored in COVID-19. We evaluated urinary CysLT (U-CysLT) relationship with disease severity and their usefulness for prognostication in hospitalized COVID-19 patients. The impact on U-CysLT of veno-venous extracorporeal membrane oxygenation (VV-ECMO) and of comorbidities such as hypertension and obesity ...
Epstein-Barr virus encephalitis presenting with brain mass lesions in a patient...
Martins, A; Silva, C; Ceia, F; Moreira, F; Reis, C; Sarmento, A; Tavares, MEpstein-Barr virus (EBV) disease of central nervous system (CNS) in human immunodeficiency virus (HIV) patients is mostly associated with primary CNS lymphoma (PCNSL). In patients who cannot undergo biopsy and have typical clinical and radiographic findings, detection of EBV deoxyribonucleic acid in CSF may provide enough evidence to start treatment for PCNSL. Here, we described a case of EBV encephalitis prese...
Proinflammatory and endothelial activation profiles in hospitalized COVID-19 pa...
Silva-Pereira, PDC; Reina-Couto, M; Alves, D; Pereira-Terra, P; Martins, S; Bessa, J; Teixeira-Santos, L; Pinho, D; Morato, M; Sarmento, A; Tavares, Mn/a
Dynamics of a Dual SARS-CoV-2 Lineage Co-Infection on a Prolonged Viral Sheddin...
Pedro, N; Silva, CN; Magalhães, AC; Cavadas, B; Rocha, AM; Moreira, AC; Gomes, MS; Silva, D; Sobrinho-Simões, J; Ramos, A; Cardoso, MJ; Filipe, RA few molecularly proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiple-component study of a clinically severe and prolonged viral shedding coronavirus disease 2019 (COVID-19) case in a 17-year-old Portuguese f...
Peripheral arterial tonometry as a method of measuring reactive hyperaemia corr...
Malheiro, LF; Gaio, R; Vaz de Silva, M; Martins, S; Sarmento, A; Santos, LPredictions of mortality may help in the selection of patients who benefit from intensive care. Endothelial dysfunction is partially responsible for many of the organic dysfunctions in critical illness. Reactive hyperaemia is a vascular response of the endothelium that can be measured by peripheral arterial tonometry (RH-PAT). We aimed to assess if reactive hyperaemia is affected by critical illness and if it c...
Impact of montelukast as add on treatment to the novel coronavirus pneumonia (C...
Tavares, M; Farraia, M; Silva, S; Ribeiro, AM; Severo, M; Paciência, I; Ribeiro, R; Hespanhol, V; Guimarães, T; Almeida, J; Magro, F; Sarmento, ABackground: Montelukast, a safe drug widely use in asthmatic patients, may be an adjuvant in the treatment of Covid-19, either by improving lung injury and inflammation, or by acting as an anti-viral drug. We aim to assess the efficacy and safety of montelukast as add-on treatment in patients with Covid-19. Methods: We propose a randomized, controlled, parallel, open-label trial involving 160 hospitalized adult...
Spatial patterns in hospital-acquired infections in Portugal (2014–2017)
Teixeira, H; Freitas, A; Sarmento, A; Nossa, P; Gonçalves, H; Pina, MFBackground: Hospital-Acquired Infections (HAIs) represent the most frequent adverse event associated with healthcare delivery and result in prolonged hospital stays and deaths worldwide. Aim: To analyze the spatial patterns of HAI incidence from 2014 to 2017 in Portugal. Methods: Data from the Portuguese Discharge Hospital Register were used. We selected episodes of patients with no infection on admission and w...
Dynamics of a dual sars-cov-2 lineage co-infection on a prolonged viral sheddin...
Pedro, N; Silva, CN; Magalhães, AC; Cavadas, B; Rocha, AM; Moreira, AC; Gomes, MS; Silva, D; Sobrinho-Simões, J; Ramos, A; Cardoso, MJ; Filipe, RA few molecularly proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiplecomponent study of a clinically severe and prolonged viral shedding coronavirus disease 2019 (COVID-19) case in a 17-year-old Portuguese fe...
Dna-based detection of mycobacterium avium subsp. Paratuberculosis in domestic ...
Sousa, T; Costa, M; Sarmento, P; Manso, MC; Abreu, C; Bull, TJ; Cabeda, J; Sarmento, AMycobacterium avium subsp. paratuberculosis (MAP) may play a role in the pathology of human inflammatory bowel disease (IBD). Previously, we found a high frequency (98% in patients with active disease) of MAP DNA detection in the blood of Portuguese Crohn s Disease patients, suggesting this cohort has high exposure to MAP organisms. Water is an important route for MAP dissemination, in this study we therefore a...