5 documents found, page 1 of 1
Fructose Malabsorption, Gut Microbiota and Clinical Consequences: A Narrative R...
Simões, Catarina D.; Sousa, Ana Sofia; Fernandes, Sofia; Sarmento, AméliaFructose malabsorption is characterized as the incomplete absorption of fructose in the small intestine. Fructose is one of the most common monosaccharides in the human diet. The purpose of this review is to provide an updated overview of insights into the relationship between high-fructose diet, fructose malabsorption, gut microbiota and clinical consequences. Incomplete absorption of fructose causes accumulat...
Type 2 Diabetes Mellitus in South Africa: socioeconomic disadvantage and associ...
Duro, Mary; Moshodi, Gomolemo; Sarmento, Amélia; Almeida, CristinaBackground: The prevalence of type 2 Diabetes Mellitus (T2DM) has been rapidly increasing worldwide. The situation in South Africa is worsening, as the population moves into a more urbanized way of life. Objectives: To analyze the prevalence of T2DM in South Africa: causes and side effects on health and economy. Methods: Review of recent research, consulting Pubmed, Google Shcolar, oficial sources from governme...
1,2-dihydroxyxanthone: effect on A375-C5 melanoma cell growth associated with i...
Silva, Viviana; Cerqueira, Fátima; Nazareth, Nair; Medeiros, R.; Sarmento, Amélia; Sousa, Emília; Pinto, MadalenaXanthones have been suggested as prospective candidates for cancer treatment. 1,2- dihydroxyxanthone (1,2-DHX) is known to interfere with the growth of several cancer cell lines. We investigated the effects of 1,2-DHX on the growth of the A375-C5 melanoma cell line and THP-1 human macrophage activity. 1,2-DHX showed a moderate growth inhibition of A375-C5 melanoma cells (concentration that causes a 50% inhibiti...
Mycobacterium avium subsp paratuberculosis detection from blood of Crohn's dise...
Martinho, António; Campos, Nair; Rodrigues, Pedro; Magro, Fernando; Sarmento, AméliaMycobacterium avium subsp paratuberculosis (MAP) has been associated with Crohn’s disease (CD). We performed MAP DNA detection in the blood of controls and CD patients followed at Hospital de São João, by IS900-based nested PCR. We found that 60% (6 out of 10) of CD patients were positive for MAP DNA, against 38% (8 out of 21) of control subjects. MAP detection in CD patients will allow us to correlate MAP infe...
Mycobacterium avium spp. paratuberculosis up-regulates CD40 expression and down...
Campos, Nair; Castro, Ana Rita; Magro, Fernando; Sarmento, Amélia; Cabral, Joana; Bacalhau, Nicole MarquesMycobacterium avium spp paratuberculosis (MAP) tem vindo a ser sugerido como um agente etiológico da doença de Crohn. Este estudo teve por objectivo avaliar os efeitos imunomoduladores do MAP em macrófagos humanos. Os macrófagos foram obtidos a partir do sangue de controlos normais ou pacientes com doença de Crohn, e infectados in vitro com MAP ou Mycobacterium avium spp. avium (MA). Os efeitos observados na pr...