6 documents found, page 1 of 1
Diagnosis and Laboratory Follow-Up of Patients with Multiple Myeloma: Guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Diagnosis and laboratory follow-up of patients with multiple myeloma: guideline...
Pires, Ana Marta; Barreto, João Pedro; Caetano, Joana; Soares, Maria José; Geraldes, Catarina; Fernandes, Bruno; Coucelo, Margarida; Chacim, SérgioMultiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...
Multiple Myeloma Treatment Guidelines by the Portuguese Group of Multiple Myeloma
João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; Esteves, Graça; Freitas, José GuilhermeThe treatment of multiple myeloma has profoundly changed with the introduction of several innovative therapies. The optimization of therapeutic sequencing through the combined use of the various drugs developed in recent years and the attention given to the characteristics of patients have allowed the reduction of toxicities and increased survival and quality of life of patients with multiple myeloma. These tre...
Gamapatias Monoclonais de Significado Indeterminado: Critérios de Diagnóstico e...
Parreira, Joana; Lúcio, Paulo; João, Cristina; Macedo, Ana; Sarmento, Ana Bela; Geraldes, Catarina; Gonçalves, Cristina; Esteves, GraçaO Grupo Português de Mieloma Múltiplo da Sociedade Portuguesa de Hematologia propôs-se criar um protocolo de avaliação e acompanhamento de doentes com gamapatias monoclonais. O protocolo aqui apresentado, meramente referencial, pretende racionalizar e uniformizar a forma como estes doentes são acompanhados pelos seus médicos assistentes e identifica critérios claros de risco de progressão que justificam a sua r...
Monoclonal Gammopathies of Indetermined Significance: Diagnosis and Clinical Fo...
Parreira, Joana; Lúcio, Paulo; João, Cristina; Macedo, Ana; Sarmento, Ana Bela; Geraldes, Catarina; Gonçalves, Cristina; Esteves, GraçaThe Portuguese group of multiple myeloma of the Portuguese Society of Hematology proposes a national protocol for diagnosis and clinical follow-up of monoclonal gammopathies. The proposed protocol aims to standardize clinical management of monoclonal gammopathies. Furthermore, it would also define the major risk factors for progression to Multiple Myeloma that require a precocious close articulation between gen...
CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukae...
Dourado, Marília; Sarmento, Ana Bela; Pereira, Sofia Vale; Alves, Vera; Silva, Teresa; Pinto, Anabela MotaDipeptidyl peptidase IV, a cell membrane surface protease also known as CD26 (CD26/DPPIV), is known to play multiple functions in human organism, where it is largely expressed, for instance, in the development of human cancer and metastasis as well as in chemotherapy response. The objective of this work was to study the CD26 membrane expression and DPPIV activity in T-acute leukaemia cell lines (CEM and MOLT3) ...