14 documents found, page 1 of 2
Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell k...
Pinto, B.; Silva, P.; Sarmento, B.; Carvalho-Tavares, J.; Bousbaa, HassanBackground: Lung cancer is the leading cause of cancer death worldwide, posing a significant public health challenge [1]. Currently available therapies, when administered as monotherapy, have limited efficacy, high toxicity, and can lead to increased tumor resistance. Overexpression of MPS-1, a protein kinase involved in mitosis, has been observed in various types of tumors. Its inhibition is associated with ab...
P3.2: Targeted cathelicidin nanomedicines as novel glucoregulator for diabetes ...
Cristelo, C.; Gama, F. M.; Sarmento, B.[Excerpt] Type 1 diabetes (T1D) is an autoimmune condition resulting in the destruction of the insulin-producing β cells. With no cure available for this disease, patients depend on insulin administration to control glycaemia. The recovery of β cells by promoting its replication, neogenesis or by reprogramming of other pancreatic cells, offers a promising strategy to revert T1D.
Natural antioxidant extracts produced from five microalgae species by enzymatic...
Cunha, S. A.; Costa-Pinto, A. R.; Sarmento, B.; Pintado, M. E.Skin aging represents a huge concern in almost all cultures in the world. The excessive production of reactive oxygen species (ROS) combined with a normal intrinsic reduced antioxidant activity are factors that deeply contribute to the aging process (1). Thus, it is important to develop strategies to decrease ROS production in the skin or reduce the damage caused by them. The valorisation of natural cosmetic in...
A biofertilizer with diazotrophic bacteria and a filamentous fungus increases P...
Silva, M. Nunes da; Pintado, M. E.; Sarmento, B.; Stamford, N. P.; Vasconcelos, M. W.The pine wilt disease (PWD), caused by the pine wood nematode (PWN) Bursaphelenchus xylophilus, is a devastating illness that mainly affects P. pinaster trees, and that poses great environmental and economic challenges. Current disease management involves the cut down of infected trees, tree fumigation, use of nematicides, or the control of the insect vector; however, these methodologies are expensive, labour-i...
Prediction of sunlight-driven CO2 conversion: producing methane from photovolta...
Vieira, F.; Sarmento, B.; Machado, Ana; Facão, Jorge; Carvalho, Maria João; Mendes, Manuel Joao; Fortunato, Elvira; Martins, RodrigoABSTRACT: CO2 capture and utilization (CCU) technologies are being immensely researched as means to close the anthropogenic carbon cycle. One approach known as artificial photosynthesis uses solar energy from photovoltaics (PV), carbon dioxide and water to generate hydrocarbon fuels, being methane (CH4) a preferential target due to the already in place infrastructures for its storage, distribution and consumpti...
Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin
Costa, J. R.; Silva, N. C.; Sarmento, B.; Pintado, M.Daptomycin may offer an antibacterial alternative for the treatment of endophthalmitis caused by methicillin-resistant Staphylococcus aureus (MRSA) and other potential agents. In the present project, mucoadhesive chitosan-coated alginate (CS-ALG) nanoparticles are proposed as an effective delivery system for daptomycin permeation across ocular epithelia, with potential for the treatment of bacterial endophthalm...
Isoflavones in food supplements: chemical profile, label accordance and permeab...
Almeida, I. M. C.; Rodrigues, F.; Sarmento, B.; Alves, R. C.; Oliveira, M. B. P. P.Consumers nowadays are playing an active role in their health-care. A special case is the increasing number of women, who are reluctant to use exogenous hormone therapy for the treatment of menopausal symptoms and are looking for complementary therapies. However, food supplements are not clearly regulated in Europe. The EFSA has only recently begun to address the issues of botanical safety and purity regulation...
Are coffee silverskin extracts safe for topical use? An in vitro and in vivo ap...
Rodrigues, F.; Pereira, C.; Pimentel, F. B.; Alves, R. C.; Ferreira, M.; Sarmento, B.; Amaral, Maria Helena; Beatriz, M.; Oliveira, P. P.Recent changes in regulatory requirements and social views on animal testing have incremented the development of reliable alternative tests for predicting skin and ocular irritation potential of products based on new raw materials. In this regard, botanical ingredients used in cosmetic products are among those materials, and should be carefully reviewed concerning the potential presence of irritant constituents...
Development and characterization of natural antioxidant-containing chitosan nan...
Silva, S. Baptista da; Oliveira, A.; Ferreira, D.; Pintado, M.; Sarmento, B.The use of nanotechnology in medical sciences is an innovation that promises a new age of health. Among the different approaches explored so far, chitosan exhibits favourable and unique biological properties, such as biocompatibility, biodegradability, nonantigenic, non-toxicity and mucoadhesiveness. Natural extracts rich in antioxidant molecules have been incorporated in chitosan films, or macro/microparticles...
Encapsulation of rosmarinic acid into chitosan nanoparticles
Silva, S. B.; Amorim, M.; Oliveira, A.; Ramos, O.; Pintado, M.; Ferreira, D.; Sarmento, B.Introduction: The use of nanotechnology in medical sciences is a innovation that promises a new age of health. Among the different approaches explored so far, chitosan exhibits favourable and unique biological properties, such as biocompatibility, biodegradability, non-antigenic, non-toxicity and mucoadhesiveness . On the other hand, natural extracts have been incorporated in chitosan films, or macro/microparti...