104 documents found, page 1 of 11

Exploring Innovations and Key Insights in Healthcare

On behalf of the Editorial Team of Scientific Letters, we are pleased to announce the publication of the third issue. The 2024 edition of Scientific Letters presents a diverse array of research that highlights significant advancements in health, dentistry, and clinical treatments.

Developing robust heterotypic 3D lung cancer cultures for drug screening: preli...

Background: To propel advancements in cancer treatment, it is imperative to conduct initial drug testing using in vitro models. In laboratory settings, the efficacy of most compounds is rigorously evaluated through 2D cell cultures. However, many compounds showing promise in these models fail to perform similarly in preclinical or clinical trials, prolonging the timeline for developing effective drugs for human...

The Brightness of Multidisciplinary Approaches in Health Sciences Research

On behalf of the Editorial Team of Scientific Letters journal, we are pleased to announce the publication of the second issue. The second issue comprises four scientific papers, encompassing two reviews and two research articles. In 2023, Scientific Letters also published two special issues in the form of Books of Abstracts. These publications compile all abstracts that were accepted for presentation at the II ...

Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E...

Increasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs p...

Appraisal of a new potential antioxidants-rich nutraceutical ingredient from ch...

Chestnut (Castanea sativa) shells (CSS) are a source of bioactive compounds with well demonstrated in-vitro antioxidant properties. Nevertheless, no in-vivo studies have already evaluated this effect. This study evaluated the effects of the oral daily administration of an eco-friendly CSS extract (50 and 100 mg/kg per body weight (b. w.)) to rats regarding in-vivo antioxidant activity, glucose and lipids levels...

Targeting cells with cathelicidin nanomedicines improves insulin function and p...

Type 1 diabetes (T1D) is an incurable condition with an increasing incidence worldwide, in which the hallmark is the autoimmune destruction of pancreatic insulin-producing β cells. Cathelicidin-based peptides have been shown to improve β cell function and neogenesis and may thus be relevant while developing T1D therapeutics. In this work, a cathelicidin-derived peptide, LLKKK18, was loaded in poly(lactic-co-gly...

Hydrolysates of mytilus galloprovincialis as a source of bioactive compounds

Mussel meat waste as a source of bioactive ingredients for industrial application

Mussels are considered a delicacy appreciated in several countries, including Portugal. For commercialization, mussels need to fulfil the market criteria, such as size and condition. Thus, before being commercialized, mussels need to be pre-selected according to the target market requirements. Consequently, broken mussels or those with size out of the established criteria are discarded, corresponding to about 2...

Insights into the 3D In Vitro Permeability and In Vivo Antioxidant Protective E...

Actinidia arguta (Siebold & Zucc.) Planch. ex Miq. (kiwiberry) leaves are a source of phenolic compounds with pro-health biological effects, such as antioxidant and anti-inflammatory activities. Despite the huge number of studies reporting the composition of A. arguta leaves, no in vitro or in vivo studies explore its potential use as nutraceutical ingredient based on these activities. Therefore, this study aim...

Exposure to PAHs during Firefighting Activities: A Review on Skin Levels, In Vi...

Occupational exposure as a firefighter is a complex activity that continuously exposes subjects to several health hazards including fire emissions during firefighting. Firefighters are exposed to polycyclic aromatic hydrocarbons (PAHs), known as toxic, mutagenic, and carcinogenic compounds, by inhalation, dermal contact, and ingestion. In this work, a literature overview of firefighters’ dermal exposure to PAHs...