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Exploring Innovations and Key Insights in Healthcare

On behalf of the Editorial Team of Scientific Letters, we are pleased to announce the publication of the third issue. The 2024 edition of Scientific Letters presents a diverse array of research that highlights significant advancements in health, dentistry, and clinical treatments.

Developing robust heterotypic 3D lung cancer cultures for drug screening: preli...

Background: To propel advancements in cancer treatment, it is imperative to conduct initial drug testing using in vitro models. In laboratory settings, the efficacy of most compounds is rigorously evaluated through 2D cell cultures. However, many compounds showing promise in these models fail to perform similarly in preclinical or clinical trials, prolonging the timeline for developing effective drugs for human...

The Brightness of Multidisciplinary Approaches in Health Sciences Research

On behalf of the Editorial Team of Scientific Letters journal, we are pleased to announce the publication of the second issue. The second issue comprises four scientific papers, encompassing two reviews and two research articles. In 2023, Scientific Letters also published two special issues in the form of Books of Abstracts. These publications compile all abstracts that were accepted for presentation at the II ...

Vitamin D loaded into lipid nanoparticles shows insulinotropic effect in INS-1E...

Increasing evidence suggests a beneficial role of vitamin D (VitD) supplementation in addressing the widespread VitD deficiency, but currently used VitD3 formulations present low bioavailability and toxicity constrains. Hence, poly(L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), solid-lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) were investigated to circumvent these issues. PLGA NPs p...

Targeting cells with cathelicidin nanomedicines improves insulin function and p...

Type 1 diabetes (T1D) is an incurable condition with an increasing incidence worldwide, in which the hallmark is the autoimmune destruction of pancreatic insulin-producing β cells. Cathelicidin-based peptides have been shown to improve β cell function and neogenesis and may thus be relevant while developing T1D therapeutics. In this work, a cathelicidin-derived peptide, LLKKK18, was loaded in poly(lactic-co-gly...

Appraisal of a new potential antioxidants-rich nutraceutical ingredient from ch...

Chestnut (Castanea sativa) shells (CSS) are a source of bioactive compounds with well demonstrated in-vitro antioxidant properties. Nevertheless, no in-vivo studies have already evaluated this effect. This study evaluated the effects of the oral daily administration of an eco-friendly CSS extract (50 and 100 mg/kg per body weight (b. w.)) to rats regarding in-vivo antioxidant activity, glucose and lipids levels...

Nanomedicine internalization and penetration: why should we use spheroids?

Cancer is a leading cause of death worldwide and, despite medical advances in the development of new anticancer therapies, drug resistance, complicated side effects and poor efficacy remain a major public health problem. To breakdown the antisuppressive tumour strategies and to improve drug efficiency, nanomedicine is increasingly being used in anticancer therapy studies. Different in vitro experimental models ...

Mussel meat waste as a source of bioactive ingredients for industrial application

Mussels are considered a delicacy appreciated in several countries, including Portugal. For commercialization, mussels need to fulfil the market criteria, such as size and condition. Thus, before being commercialized, mussels need to be pre-selected according to the target market requirements. Consequently, broken mussels or those with size out of the established criteria are discarded, corresponding to about 2...

Hydrolysates of mytilus galloprovincialis as a source of bioactive compounds

Local bone metabolism balance regulation via double-adhesive hydrogel for fixin...

The effective osteointegration of orthopedic implants is a key factor for the success of orthopedic surgery. However, local metabolic imbalance around implants under osteoporosis condition could jeopardize the fixation effect. Inspired by the bone structure and the composition around implants under osteoporosis condition, alendronate (A) was grafted onto methacryloyl hyaluronic acid (H) by activating the carbox...