4 documents found, page 1 of 1
Feedforward postural adjustments before single leg droplanding in subjects with...
Sousa, Andreia; Sarmento, Leonor; Gouveia, Ana; Ribeiro, Rui; Nunes, Ana RitaChronic ankle instability (CAI) involves deregulation of feedforward postural control. But the analysis of feedforward mechanisms, including early and anticipatory postural adjustments, in tasks close to the mechanisms of injury is still missing.
Postural adjustments during single leg droplanding in subjects with chronic ank...
Sousa, Andreia; Ribeiro, Rui; Nunes, Ana Rita; Sarmento, Leonor; Gouveia, AnaChronic ankle instability (CAI) involves deregulation of postural control mechanisms and is estimated to occur in 70% of the individuals after ankle SPRAIN.
CHK1 and replicative stress in T-cell leukemia: can an irreverent tumor suppres...
Sarmento, Leonor; Barata, João T.Replicative stress (RS) is a cell-intrinsic phenomenon enhanced by oncogenic transformation. Checkpoint kinase 1 (CHK1) is a key component of the ATR-dependent DNA damage response pathway that protects cells from RS by preventing replication fork collapse and activating homologous DNA repair. Taking this knowledge into account, one would predict CHK1 behaves strictly as a tumor suppressor. However, the reality ...
Checkmate to CHK1 in T-cell ALL?
Sarmento, Leonor; Barata, João T.DNA replication ensures accurate duplication of the original genetic information present in a cell in order for it to be properly transmitted to daughter cells. However, replication can be perturbed, for instance in rapidly dividing cancer cells, in a process referred to as replication stress (RS). Checkpoint kinase 1 (CHK1) is an essential component of the ATR-dependent DNA damageresponse pathway that protect ...