2 documents found, page 1 of 1
Batimastat Induces Cytotoxic and Cytostatic Effects in In Vitro Models of Hemat...
Alves, Raquel; Pires, Ana; Jorge, Joana; Balça-Silva, Joana; Gonçalves, Ana Cristina; Sarmento Ribeiro, Ana BelaThe role of metalloproteinases (MMPs) in hematological malignancies, like acute myeloid leukemia (AML), myelodysplastic neoplasms (MDS), and multiple myeloma (MM), is well-documented, and these pathologies remain with poor outcomes despite treatment advancements. In this study, we investigated the effects of batimastat (BB-94), an MMP inhibitor (MMPi), in single-administration and daily administration schemes i...
CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukem...
Rodrigues, Cristiana; Laranjeira, Paula; Pinho, A. C. O.; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana Catarina; Simões, Ana TeresaIntroduction: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. Methods: Here, we quantified and phenotypically characterized CD20...