4 documents found, page 1 of 1
Engineering the activity and specificity of Saccharomyces cerevisiae Acetate Tr...
Rendulic, Toni; Alves, João; Soares-Silva, Isabel João; Nevoigt, Elke; Casal, MargaridaOrganic acids are industrially relevant chemicals with application in polymer, food, agricultural and pharmaceutical sectors. Yeasts commonly represent the organisms of choice for production of organic acids, namely due to their tolerance of low pH environments since such production conditions allow for direct formation of the desired protonated form of the acid and thus cut downstream processing costs. Since o...
New insights into the acetate uptake transporter (AceTr) family: Unveiling amin...
Rendulic, Toni; Alves, João; Azevedo-Silva, João; Soares-Silva, Isabel; Casal, MargaridaAiming at improving the transport of biotechnologically relevant carboxylic acids in engineered microbial cell factories, the focus of this work was to study plasma membrane transporters belonging to the Acetate Uptake Transporter (AceTr) family. Ato1 and SatP, members of this family from Saccharomyces cerevisiae and Escherichia coli, respectively, are the main acetate transporters in these species. The analysi...
Engineering of AceTr membrane transporters to improve organic acid production i...
Rendulic, Toni; Silva, João Pedro Azevedo; Ribas, David Manuel Nogueira; Castagnoli, Davide; Paiva, Sandra; Soares-Silva, Isabel João; Nevoigt, ElkeOrganic acids are industrially relevant chemicals obtainable from renewable feedstocks via microbial cell factories. Microbially produced organic acids have a wide variety of applications, including bioplastic synthesis. Thus, they possess the potential to replace petroleum-derived commodity chemicals that are obtained through unsustainable production processes. Yeasts commonly represent the organisms of choice...
Exploring plasma membrane transporters to improve organic acid production in ye...
Rendulic, Toni; Silva, João Pedro Azevedo; Xiberras, Joeline; Medonça Bahia, Frederico; Ribas, David Manuel Nogueira; Castagnoli, Davide; Paiva, SandraOrganic acids are industrially relevant building-block chemicals obtainable from renewable feedstocks by utilization of microbial cell factories. With a wide variety of applications, including bioplastics synthesis, microbially produced organic acids have the potential to replace petroleum-derived commodity chemicals that are obtained through unsustainable production processes. Yeasts commonly represent the org...