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Novel polymeric nanoparticles as nanofertilisers for alkaline iron‐deficient co...

Pinho, Simão; Santos, Carla; Moniz, Tânia; Granja, Andreia; Sarraguça, Mafalda; Reis, Salette; Rangel, Maria; Vasconcelos, Marta

Background and aims Iron deficiency chlorosis (IDC) is a nutritional disorder impacting plants and is prevalent in calcareous alkaline soils, correspond- ing to 30% of the world’s arable land. IDC compro- mises iron uptake in crops such as soybean (Glycine max). To improve the effect of iron fertilisers, we sought to develop a nanotechnology-based interven- tion using polymeric nanoparticles (NPs) loaded with F...



A novel HPLC method for the determination of zonisamide in human plasma using m...

Lourenço, Dina; Sarraguça, Mafalda; Alves, Gilberto; Coutinho, Paula; Araújo, André; Rodrigues, Márcio

A novel high-performance liquid chromatography-diode array detection method based on microextraction by packed sorbent (MEPS) as a sample preparation approach is described for the determination of zonisamide (ZNS) in human plasma. MEPS parameters were optimised using a Plackett–Burman experimental design to achieve the best extraction conditions. The chromatographic separation of ZNS and chloramphenicol [intern...


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