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Peptide anchor for folate-targeted liposomal delivery

Nogueira, E.; Mangialavori, Irene C.; Loureiro, Ana; Azóia, Nuno G.; Sarria, Marisa P.; Nogueira, Patrícia; Freitas, Jaime; Harmark, Johan

Specific folate receptors are abundantly overexpressed in chronically activated macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is formed using a large spacer like polyethylene glycol. Here, we report an innovative strategy for targeted liposome delivery that uses a hydrophobic fra...

Date: 2015   |   Origin: RepositóriUM - Universidade do Minho
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