3 documents found, page 1 of 1
Innate immunity and effector and regulatory mechanisms involved in allergic con...
Silvestre,Marilene Chaves; Sato,Maria Notomi; Reis,Vitor Manoel Silva dosAbstract: Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TNF, IL-1β, and IL-18, contributing to the development o...
Atopic dermatitis in adults: clinical and epidemiological considerations
Orfali,Raquel Leão; Shimizu,Marta M.; Takaoka,Roberto; Zaniboni,Mariana C.; Ishizaki,Aline S.; Costa,Anderson A.; Tiba,Ana Paula L.; Sato,Maria NotomiOBJECTIVE: Atopic dermatitis (AD) is a chronic inflammatory disease causing intense pruritus, and with typical clinical features. There are few epidemiological studies concerning AD in adults, as well as little information about its prognostic. The aim of this study was to evaluate the clinical and epidemiological course of adults with AD. METHODS: 80 patients aged above 18 years (mean age = 29 years) were sele...
Estudo da proliferação linfocitária em pacientes sensibilizados ao níquel
Sanchez,Ana Paula Galli; Maruta,Celina Wakisaka; Sato,Maria Notomi; Ribeiro,Ricardo Luiz; Zomignan,Carolina de Almeida; Nunes,Ricardo SpinaFUNDAMENTO: O diagnóstico da alergia ao níquel é estabelecido com a realização do teste de contato. OBJETIVO: Desenvolver um método diagnóstico mais sensível e específico. CASUÍSTICAS E MÉTODOS: Dezenove pacientes com teste de contato positivo para o níquel e 25 controles foram submetidos ao teste da proliferação linfocitária. As células mononucleadas foram isoladas do sangue venoso periférico e cultivadas em t...