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Improving quality and patient safety in surgical care through standardisation a...

Valli, Claudia; Schäfer, Willemijn L.A.; Bañeres, Joaquim; Groene, Oliver; Arnal-Velasco, Daniel; Leite, Andreia; Suñol, Rosa; Ballester, Marta

Introduction: Adverse events in health care affect 8% to 12% of patients admitted to hospitals in the European Union (EU), with surgical adverse events being the most common types reported. Aim: SAFEST project aims to enhance perioperative care quality and patient safety by establishing and implementing widely supported evidence-based perioperative patient safety practices to reduce surgical adverse events. Met...


Impacte direto e indireto da Pandemia COVID-19 na mortalidade por todas as caus...

Rodrigues, Ana Paula; Leite, Andreia; Machado, Ausenda; Nunes, Baltazar; Matias Dias, Carlos; Barreto, Marta; Soares, Patricia; Sá, Regina

Introdução: Durante a pandemia de COVID-19 foram observados excessos de mortalidade muito elevados e muito superiores aos observados no período pré-pandemia. No entanto, é menor a evidência sobre o impacte direto (devido à infeção e suas complicações) e indireto (em consequência das medidas não farmacológicas e das alterações no acesso e procura de cuidados de saúde). Este trabalho teve como objetivo colmatar e...


Is a tiered restrictions system an effective intervention for COVID-19 control?...

Moniz, Marta; Soares, Patricia; Nunes, Baltazar; Leite, Andreia

Background: In November 2020, similar to other European countries, Portugal implemented a tiered restrictions system to control the COVID-19 pandemic. We aimed to compare the COVID-19 growth rate across tiers to assess the effect of a tiered restrictions system in Portugal, using models with different times between tiers assessment. Our hypothesis was that being in a higher tier brings a faster deceleration in ...


Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study i...

Queiroz, Guilherme; Monteiro, Celdidy; Manco, Licínio; Relvas, Luís; Trovoada, Maria de Jesus; Leite, Andreia; Bento, Celeste

Background Sickle Cell Disorder is Africa’s most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors. Methods: We cond...


Moving towards a core measures set for patient safety in perioperative care: An...

Dinis-Teixeira, J.P.; Nunes, Ana Beatriz; Leite, Andreia; Schäfer, Willemijn L.A.; Valli, Claudia; Martínez-Nicolas, Ismael; Seyfulayeva, Ayshe

A Core Measures Set (CMS) is an agreed standardized group of measures that should be assessed and reported in research for a specific condition or clinical area. This study undertook the development of a CMS for Patient Safety through a two-round, web-based Delphi consensus approach, in the context of the "Improving quality and patient SAFEty in surgical care through STandardisation and harmonization of periope...


Microfluidic paper-based device incorporated with silica nanoparticles for iodi...

Pereira, Mafalda G.; Machado, Ana; Leite, Andreia; Rangel, Maria; Bordalo, Adriano; Rangel, António O. S. S.; Mesquita, Raquel B. R.

Iodine is an essential micronutrient for humans due to its fundamental role in the biosynthesis of thyroid hormones. As a key parameter to assess health conditions, iodine intake needs to be monitored to ascertain and prevent iodine deficiency. Iodine is available from various food sources (such as seaweed, fish, and seafood, among others) and dietary supplements (multivitamins or mineral supplements). In this ...


Use of a rhodamine-based chelator in a microfluidic paper-based analytical devi...

Aguiar, Juliana I. S.; Ribeiro, Susana O.; Leite, Andreia; Rangel, Maria; Rangel, António O. S. S.; Mesquita, Raquel B. R.

This work describes the development of a microfluidic paper-based analytical device (μPAD) for the determination of copper in fresh and marine waters. A functionalized rhodamine-based chelator was synthesized and used as a chromogenic reagent, forming a highly intense pink complex with the analyte. The aim was to create a paper device that offers optimal performance and provides in-situ, rapid and cost-effectiv...


Optimizing antimicrobial efficacy: investigating the impact of zinc oxide nanop...

Mendes, Ana Rita; Granadeiro, Carlos M.; Leite, Andreia; Pereira, Eulália; Teixeira, Paula; Poças, Fátima

Zinc oxide nanoparticles (ZnO NPs) have been investigated due to their distinct properties, variety of structures and sizes, and mainly for their antimicrobial activity. They have received a positive safety evaluation from the European Food Safety Authority (EFSA) for packaging applications as transparent ultraviolet (UV) light absorbers based on the absence of significant migration of zinc oxide in particulate...


Long COVID is not the same for everyone: a hierarchical cluster analysis of Lon...

Moniz, Marta; Ruivinho, Carolina; Goes, Ana Rita; Soares, Patricia; Leite, Andreia

Background: Identifying symptom clusters in Long COVID is necessary for developing effective therapies for this diverse condition and improving the quality of life of those affected by this heterogeneous condition. In this study, we aimed to identify and compare symptom clusters at 9 and 12 months after a SARS-CoV-2 positive test and describe each cluster regarding factors at infection. Methods: This is a cross...


Individual risk factors associated with SARS-CoV-2 infection during Alpha varia...

Moniz, Marta; Pereira, Sofia; Soares, Patricia; Aguiar, Pedro; Donato, Helena; Leite, Andreia

Objectives: This study aimed to systematically appraise risk factors associated with SARS-CoV-2 infection in high-income countries during the period of predominance of the Alpha variant (January 2020 to April 2021). Methods: Four electronic databases were used to search observational studies. Literature search, study screening, data extraction and quality assessment were conducted by two authors independently. ...


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