6 documents found, page 1 of 1
Deep learning system to predict the 5-year risk of high myopia using fundus ima...
Foo, Li Lian; Lim, Gilbert Yong San; Lança, Carla; Wong, Chee Wai; Hoang, Quan V.; Zhang, Xiu Juan; Yam, Jason C.; Schmetterer, Leopold; Chia, AudreyOur study aims to identify children at risk of developing high myopia for timely assessment and intervention, preventing myopia progression and complications in adulthood through the development of a deep learning system (DLS). Using a school-based cohort in Singapore comprising 998 children (aged 6-12 years old), we train and perform primary validation of the DLS using 7456 baseline fundus images of 1878 eyes;...
Systematic review and meta-analysis on the impact of COVID-19 pandemic-related ...
Li, Mijie; Xu, Lingqian; Tan, Chuen-Seng; Lança, Carla; Foo, Li-Lian; Sabanayagam, Charumathi; Saw, Seang-MeiPurpose: To conduct a systematic review and meta-analysis to assess the effects of coronavirus disease 2019 (COVID-19) pandemic–related lifestyle on myopia outcomes in children to young adults. Methods: A systematic search was conducted on PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases (with manual searching of reference lists of reviews). Studies included assessed changes in m...
The potential of current polygenic risk scores to predict high myopia and myopi...
Kassam, Irfahan; Foo, Li-Lian; Lança, Carla; Xu, Ling Qian; Hoang, Quan V.; Cheng, Ching-Yu; Hysi, Pirro; Saw, Seang-MeiPurpose: To evaluate the trans-ancestry portability of current myopia polygenic risk scores (PRS) to predict high myopia (HM) and myopic macular degeneration (MMD) in an Asian population. Design: Population-based study. Subjects: A total of 5,894 (2,141 Chinese, 1,913 Indians, and 1,840 Malays) adults from the Singapore Epidemiology of Eye Diseases (SEED) study were included in the analysis. The mean age was 57...
New polygenic risk score to predict high myopia in Singapore Chinese children
Lança, Carla; Kassam, Irfahan; Patasova, Karina; Foo, Li-Lian; Li, Jonathan; Ang, Marcus; Hoang, Quan V.; Teo, Yik-Ying; Hysi, Pirro G.; Saw, Seang-MeiPurpose: The purpose of this study was to develop an Asian polygenic risk score (PRS) to predict high myopia (HM) in Chinese children in the Singapore Cohort of Risk factors for Myopia (SCORM) cohort. Methods: We included children followed from 6 to 11 years old until teenage years (12–18 years old). Cycloplegic autorefraction, ultrasound biometry, Illumina HumanHap 550, or 550 Duo Beadarrays, demographics, and...
Cost of myopia correction: a systematic review
Foo, Li Lian; Lança, Carla; Wong, Chee Wai; Ting, Daniel; Lamoureux, Ecosse; Saw, Seang-Mei; Ang, MarcusMyopia is one of the leading causes of visual impairment globally. Despite increasing prevalence and incidence, the associated cost of treatment remains unclear. Health care spending is a major concern in many countries and understanding the cost of myopia correction is the first step eluding to the overall cost of myopia treatment. As the cost of treatment will reduce the burden of the cost of illness, this wi...
Associations of childcare arrangements with adiposity measures in a multi-ethni...
Wong, Beverly Wen-Xin; Toh, Jia Ying; Sugianto, Ray; Chia, Airu; Tint, Mya Thway; Yuan, Wen Lun; Padmapriya, Natarajan; Lança, Carla; Saw, Seang-MeiChildcare arrangements shape behavioural patterns that influence the risk of childhood obesity. However, little is known of its influence on childhood obesity in Singapore. We aim to examine the associations between childcare arrangements at the age of 5 years and childhood adiposity at age 6 years. Children from the GUSTO study were grouped into three childcare arrangements at age 5: full-time center-based chi...