6 documents found, page 1 of 1
Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptos...
Coelho Cavalcanti, Bruno; Costa, Patrícia Marçal da; Carvalho, Adriana Andrade Carvalho; Rodrigues, Francisco Augusto Rocha Santos; Amorim, Rodrigo C.N.Context: Quassinoids are biologically active secondary metabolites found exclusively in the Simaroubaceae family of plants. These compounds generally present important biological properties, including cytotoxic and antitumor properties. Objective: In the present study, the cytotoxic effects of neosergeolide, a quassinoid isolated from Picrolemma sprucei Hook. f., were evaluated in human promyelocytic leukemia c...
Cytotoxic and toxicological effects of phthalimide derivatives on tumor and nor...
Ferreira, Paulo Michel Pinheiro; Costa, Patrícia Marçal da; Costa, Arinice de Menezes; Lima, Daisy Jereissati Barbosa; Drumond, Renata RosadoEleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT and Alamar Blue assays. Following, the investigation of cytotoxicity was executed by flow cytometry analysis and antitu...
Perfil de flavonoides e avaliação do potencial antioxidante e citotóxico de Bau...
Santos, Priscila Moraes dos; Almeida, Patrícia Danielle Oliveira de; Lima, Emerson Silva; Moraes Filho, Manoel Odorico de; Costa, Patrícia Marçal daBauhinia purpurea (Fabaceae). Plants of the Bauhinia species (Fabaceae) are used in the treatment of several infections and diseases, especially diabetes. In this paper, with an aim to contribute to the knowledge of the chemistry and therapeutic potential of the Amazonian species of the genus Bauhinia, flavonoid profiles in the leaves and branches of Bauhinia purpurea collected in Manaus and São Gabriel da Cach...
In vivo antitumoural activity and composition of an oil extract of Brazilian pr...
Carvalho, Adriana Andrade; Finger, Daiane; Machado, Christiane Schinieder; Schmid, Eduardo Morgado; Costa, Patrícia Marçal daThe present study aimed to evaluate in vivo and in vitro the antitumoural activity of a propolis extract obtained with edible vegetable oil and its fractions and also to investigate its chemical composition by LC–MS and LC–MS/MS. To evaluate the toxicological aspects related to the propolis extract treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were per- f...
Inhibition of metastatic potential of B16-F10 melanoma cell line in vivo and in...
Carvalho, Adriana Andrade; Costa, Patrícia Marçal da; Souza, Luciana Gregório da Silva; Lemos, Telma Leda Gomes de; Alves, Ana Paula Negreiros NunesAim: The aim of this study was to determine the antimetastatic potential of bi fl orin using in vivo and in vitro approaches. Main methods: Bi fl orin was isolated from Capraria bi fl ora collected in Fortaleza, Ceará, Brazil. Adhesion, migra- tion and invasion assays were performed to avail of the antimetastatic potential of this quinone. Experimen- tal metastasis was performed to avail of the antimetastatic p...
Avaliação do potencial antitumoral dos hidrobenzofuranóides isolados das folhas...
Costa, Patrícia Marçal daThe hydrobenzofuranoids obtained from Tapirira guianensis are alkylated derivates of cyclo-hexanone, which appear to be precursors of phenolic lipids. The present study initially examined the activity of nine hydrobenzofuranoids in cell lines, where the compound SJC-8 showed the highest cytotoxicity. In later studies, the cytotoxicity of this sample was investigated with regard to the possible mechanism of acti...