2 documents found, page 1 of 1
Role of Genetic Ancestry in 1,002 Brazilian Colorectal Cancer Patients From Bar...
Durães, RO; Berardinelli, GN; Costa, AM; Scapulatempo-Neto, C; Pereira, R; Oliveira, MA; Guimarães, DP; Reis, RMBackground: Colorectal cancer (CRC) is the third most frequent and the second deadliest cancer worldwide. The ethnic structure of the population has been gaining prominence as a cancer player. The purpose of this study was to determine the genetic ancestry of Brazilian CRC patients. Moreover, we intended to interrogate its impact on patients' clinicopathological features. Methods: Retrospective observational co...
Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GI...
Campanella, Natália C; Celestino, Ricardo; Pestana, Ana; Scapulatempo-Neto, C; Oliveira, Antonio Talvane de; Brito, Maria josé; Gouveia, AntónioSomatic mutations in the promoter region of telomerase reverse transcriptase (TERT) gene, mainly at positions c.-124 and c.-146 bp, are frequent in several human cancers; yet its presence in gastrointestinal stromal tumor (GIST) has not been reported to date. Herein, we searched for the presence and clinicopathological association of TERT promoter mutations in genomic DNA from 130 bona fide GISTs. We found TERT...