57 documents found, page 1 of 6
Frequency of Human Papillomavirus Detection in Chagasic Megaesophagus Associate...
Munari, Fernanda Franco; Sichero, Laura; Carloni, Adriana Cruvinel; Lacerda, Croider Franco; Nunes, Emily Montosa; De Oliveira, Antônio Talvane TorresMade available in DSpace on 2022-04-29T08:35:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Background: Chagasic megaesophagus (CM) as well as the presence of human papillomavirus (HPV) has been reported as etiological factors for esophageal squamous cell carcinoma (ESCC). Objective: We assessed the prevalence of HPV DNA in a series of ESCCs associated or not with CM. Data obtained were furthe...
Inflammatory breast cancer: Clinical implications of genomic alterations and mu...
Faldoni, Flávia L. C.; Villacis, Rolando A. R.; Canto, Luisa M.; Fonseca-Alves, Carlos E. [UNESP]; Cury, Sarah S. [UNESP]; Larsen, Simon J.Made available in DSpace on 2021-06-25T10:34:59Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01; Inflammatory breast cancer (IBC) is a rare and aggressive type of breast cancer whose molecular basis is poorly understood. We performed a comprehensive molecular analysis of 24 IBC biopsies naïve of treatment, using a high-resolution microarray platform and targeted next-generation sequencing (105 canc...
Comprehensive analysis of DNA methylation and prediction of response to neoadju...
Canto, Luisa Matos Do; Barros-Filho, Mateus Camargo; Rainho, Cláudia Aparecida [UNESP]; Marinho, Diogo; Kupper, Bruna Elisa CatinMade available in DSpace on 2021-06-25T11:05:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Universidade Estadual Paulista; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); The treatment for locally advanced rectal carcinomas (LARC) is based on neoadjuvant chemoradiotherapy (nCRT) and surgery, which resul...
Analysis of RPL37A, MTSS1, and HTRA1 expression as potential markers for pathol...
Carrara, Guilherme Freire Angotti; Evangelista, Adriane Feijo; Scapulatempo-Neto, Cristovam; Abrahão-Machado, Lucas Faria; Morini, Mariana AndoziaMade available in DSpace on 2021-06-25T10:33:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Background: Non-metastatic locally advanced breast carcinoma (LABC) treatment involves neoadjuvant chemotherapy (NCT). We evaluated the association of clinical–pathological data and immunoexpression of hormone receptors, HER2 and Ki67, and n...
Human papillomavirus is not associated to non-small cell lung cancer: data from...
Silva, Estela Maria; Mariano, Vânia Sammartino; Pastrez, Paula Roberta Aguiar; Pinto, Miguel Cordoba; Nunes, Emily Montosa; Sichero, LauraBackground: The pathogenesis of lung cancer is triggered by a combination of genetic and environmental factors, being the tobacco smoke the most important risk factor. Nevertheless, the incidence of lung cancer in non-smokers is gradually increasing, which demands the search for different other etiological factors such as occupational exposure, previous lung disease, diet among others. In the early 80's a theor...
EGF+61 A>G polymorphism is not associated with lung cancer risk in the Brazilia...
Laus, Ana Carolina; de Paula, Flavia Escremim; de Lima, Marcos Alves; Carlos, Carolina Dias; Gomes, Izabela Natalia Faria; de Marchi, PedroEpidermal growth factor (EGF) and its receptor (EGFR) play an important role in lung carcinogenesis. A functional single nucleotide polymorphism (SNP) in EGF promoter region (EGF+61 A>G-rs4444903) has been associated with cancer susceptibility. Yet, in lung cancer, the EGF+61 A>G role is unclear. The aim of this study was to evaluate the risk of lung cancer associated with EGF+61 A>G SNP in the Brazilian popula...
Mutational profle of Brazilian lung adenocarcinoma unveils association of EGFR ...
Leal, Letícia Ferro; Paula, Flávia Escremim de; De Marchi, Pedro; Viana, Luciano de Souza; Pinto, Gustavo Dix Junqueira; Carlos, Carolina DiasLung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a large Brazilian series of lung adenocarcinoma together with patients' genetic ancestry, clinicop...
Locally advanced rectal cancer transcriptomic-based secretome analysis reveals ...
Canto, Luisa Matos do; Cury, Sarah Santiloni [UNESP]; Barros-Filho, Mateus Camargo; Kupper, Bruna Elisa Catin; Begnami, Maria Dirlei Ferreira de SouzaMade available in DSpace on 2019-10-06T17:12:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Most patients with locally advanced rectal cancer (LARC) present incomplete pathological response (pIR) to neoadjuvant chemoradiotherapy (nCRT). Despite the efforts to pre...
PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated ...
Munari, Fernanda Franco; Cruvinel-Carloni, Adriana; Lacerda, Croider Franco; De Oliveira, Antônio Talvane Torres; Scapulatempo-Neto, CristovamMade available in DSpace on 2019-10-06T16:11:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-29; Background: Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood. Objective: We analyzed hotspot PIK3CA gene mutations in a series...
Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of i...
Marques, Marcia M.; Evangelista, Adriane F.; Macedo, Taciane; Vieira, Rene Aloisio da Costa; Scapulatempo-Neto, Cristovam; Reis, Rui M.OBJECTIVE: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. Some miRNAs, including let-7a and miR-195, have been described as tumor suppressors. However, the roles of these microRNAs in breast cancer progression remain controversial. The aim of this study is to evaluate miR-195 and let-7a expression as potential biomarkers of invasive breast cancer. ME...