13 documents found, page 1 of 2
Prenatal exposure to a mixture of different phthalates increases the risk of ma...
de Freitas, Thiago [UNESP]; Zapaterini, Joyce R. [UNESP]; Moreira, Cristiane M. [UNESP]; de Aquino, Ariana M. [UNESP]; Alonso-Costa, Luiz G. [UNESP]Made available in DSpace on 2022-04-28T19:43:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01; Phthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Daw...
Exposure to aluminium chloride during the peripuberal period induces prostate d...
Leal, Franciely A.V.D.; Gonçalves, Gessica D.; Soncini, João Gabriel M.; Staurengo-Ferrari, Larissa; Fattori, Victor; Verri Jr, Waldiceu A.Made available in DSpace on 2022-04-28T19:49:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Aluminium (Al) is an important metal, but it can be toxic including for prostate tissue. This study aimed to evaluate whether exposure to aluminium chloride (AlCl3) during the peripubertal period affects ventral prostate development i...
Increased oxidative stress and cancer biomarkers in the ventral prostate of old...
Portela, Luiz M. F. [UNESP]; Santos, Sergio A. A. [UNESP]; Constantino, Flavia B. [UNESP]; Camargo, Ana C. L. [UNESP]; Colombelli, Ketlin T. [UNESP]Made available in DSpace on 2021-06-25T11:50:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The concept of Developmental Origins of Health and Disease (DOHaD) states that exposure to malnutrition early in life increase the incidence of non-communicable chronic di...
Arsenic exposure during prepuberty alters prostate maturation in pubescent rats
Aquino, Ariana M. [UNESP]; Salata, Giovanna C. [UNESP]; Pinho, Cristiane F. [UNESP]; de Freitas, André T.A.G. [UNESP]; Périco, Larissa L. [UNESP]Made available in DSpace on 2019-10-06T15:50:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-10-01; Arsenic is a widely dispersed chemical compound in the environment and has been associated with the development of some diseases and different types of cancer. Little is known about the action of arsenic compounds on prostate development during prepuberty and puberty. This study evaluated prostate morph...
Maternal Low-Protein Diet Impairs Prostate Growth in Young Rat Offspring and In...
Santos, Sergio A A [UNESP]; Camargo, Ana C. [UNESP]; Constantino, Flávia B [UNESP]; Colombelli, Ketlin T. [UNESP]; Mani, Fernanda [UNESP]Made available in DSpace on 2019-10-06T16:17:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-05-16; Carcinogenesis is frequently linked to genetic background, however, exposure to environmental risk factors has gained attention as the etiologic agent for several types of cancer, including prostate. The intrauterine microenvironment has been described as a preponderant factor for offspring health; and ...
Mitochondrial-related gene associated to obesity can be modulated by in utero h...
Silveira, Maruhen A.D. [UNESP]; Marcondes, João Paulo C. [UNESP]; Lara, Juliana R. [UNESP]; Scarano, Wellerson R. [UNESP]Made available in DSpace on 2019-10-06T16:18:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); We investigated whether mitochondrial-related genes and proteins are modulated by hyperglycemia promoted by gestational diabetes (GDM), thereby increasing neonate obesity ...
Can resveratrol attenuate testicular damage in neonatal and adult rats exposed ...
Erthal, Rafaela P.; Siervo, Glaucia E. M. L.; Silveira, Livia T. R. [UNESP]; Scarano, Wellerson R. [UNESP]; Fernandes, Glaura S. A.Made available in DSpace on 2018-11-26T17:48:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-02-01; State of Parana Research Foundation (Araucaria Foundation); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is considered one of the most toxic dioxins. The effects of TCDD are exerted via binding to the aryl hydrocarbon receptor (AhR). The...
Maternal Resveratrol Treatment Reduces the Risk of Mammary Carcinogenesis in Fe...
de Lima e Silva, Tássia C. [UNESP]; da Silveira, Livia T. R. [UNESP]; Fragoso, Mariana F. [UNESP]; da Silva, Flávia R. M. [UNESP]Made available in DSpace on 2018-12-11T17:13:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-12-01; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) presents adverse effects on breast development/carcinogenesis. This study aimed to identify the ability of resveratrol (Res) to modify the adverse effects of TCDD in a female offspring. Pregnant female Wistar rats were allocated into four groups: TCDD, TCDD + R...
Regulatory and junctional proteins of the blood-testis barrier in human Sertoli...
de Freitas, André Teves Aquino Gonçalves [UNESP]; Ribeiro, Mariana Antunes [UNESP]; Pinho, Cristiane Figueiredo [UNESP]; Peixoto, André Rebelo [UNESP]Made available in DSpace on 2018-12-11T17:27:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-08-01; The blood-testis barrier (BTB) is responsible for providing a protected environment and coordinating the spermatogenesis. Endocrine disruptors (EDs) might lead to infertility, interfering in the BTB structure and modulation. This study aimed to correlate the actions of two EDs, monobutyl phthalate (MBP)...
Integrative transcriptome and microRNome analysis identifies dysregulated pathw...
Ribeiro, Mariana A. [UNESP]; Estill, Molly S.; Fernandez, Geysson J. [UNESP]; Moraes, Leonardo N. [UNESP]; Krawetz, Stephen A.Made available in DSpace on 2018-12-11T16:54:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-11-01; Male fertility and spermatogenesis are directly linked to the Sertoli cell's ability to produce factors associated with germ cell development. Sertoli cells express receptors for FSH and testosterone, and are the major regulators of spermatogenesis. Recent studies report that regulatory RNA molecules, s...