12 documents found, page 1 of 2
Prenatal alcohol exposure affects renal function in overweight schoolchildren: ...
Correia-Costa, L; Schaefer, F; Afonso, AC; Correia, S; Guimarães, JT; Guerra, A; Barros, H; Azevedo, ABackground: Prenatal ethanol exposure has been shown to reduce nephron endowment in animal models, but the effect of alcohol during human pregnancy on postnatal kidney function has not been explored. We aim to investigate the potential association of maternal alcohol consumption during pregnancy with the offspring renal function, considering potential confounding by intrauterine growth and children’s current nu...
Longer duration of obesity is associated with a reduction in urinary angiotensi...
Morato, M; Correia-Costa, L; Sousa, T; Cosme, D; Schaefer, F; Areias, JC; Guerra, A; Afonso, AC; Barros, H; Azevedo, A; Albino-Teixeira, ABackground: We aimed to study the impact of obesity on urinary excretion of angiotensinogen (U-AGT) in prepubertal children, focusing on the duration of obesity and gender. Also, we aimed to evaluate whether plasma angiotensinogen (P-AGT) and hydrogen peroxide (H2O2) play a role in the putative association. Methods: Cross-sectional evaluation of 305 children aged 8–9 years (160 normal weight, 86 overweight, and...
Oxidative stress and nitric oxide are increased in obese children and correlate...
Correia-Costa, L; Sousa, T; Morato, M; Cosme, D; Afonso, J; Areias, JC; Schaefer, F; Guerra, A; Caldas-Afonso, A; Azevedo, A; Albino-Teixeira, AOxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8-9 years. Anthropo...
Urinary fibrogenic cytokines ET-1 and TGF-beta 1 are associated with urinary an...
Correia-Costa, L; Morato, M; Sousa, T; Cosme, D; Guimaraes, JT; Guerra, A; Schaefer, F; Caldas-Afonso, A; Azevedo, A; Albino-Teixeira, ABACKGROUND:Fibrogenic cytokines are recognized as putative drivers of disease activity and histopathological deterioration in various kidney diseases. We compared urinary transforming growth factor β1 (U-TGF-β1) and endothelin 1 (U-ET-1) levels across body mass index classes and assessed their association with the level of urinary angiotensinogen (U-AGT), a biomarker of intrarenal renin-angiotensin-aldosterone ...
Association of myeloperoxidase levels with cardiometabolic factors and renal fu...
Costa, L; Sousa, T; Morato, M; Cosme, D; Afonso, J; Moura, C; Mota, C; Areias, JC; Guerra, A; Schaefer, F; Afonso, AC; Barros, H; Albino-Teixeira, AINTRODUCTION: Myeloperoxidase (MPO), an enzyme linking obesity and cardiovascular (CV) risk in adults, has rarely been studied in young children and no studies assessed its association with renal function. We sought to explore a possible association between serum MPO levels, obesity, CV risk factors and renal function in prepubertal children. MATERIALS/METHODS: Cross-sectional evaluation of 309 children aged 8-...
Determinants of carotid-femoral pulse wave velocity in prepubertal children
Correia-Costa, A; Correia-Costa, L; Caldas-Afonso, A; Schaefer, F; Guerra, A; Moura, C; Mota, C; Barros, H; Areias, JC; Azevedo, ABACKGROUND: Pulse wave velocity (PWV) is a noninvasive technique to evaluate arterial stiffness, a dynamic property of the vessels, reflecting their structure and function. Childhood obesity is associated with several cardiovascular comorbidities and to the progression of atherosclerosis. We aimed to compare carotid-femoral PWV between normal weight and overweight/obese prepubertal children and to quantify its ...
Accelerated growth during childhood is associated with increased arterial stiff...
Pais, C; Correia-Costa, L; Moura, C; Mota, C; Severo, M; Guerra, A; Areias, JC; Schaefer, F; Caldas-Afonso, C; Barros, H; Santos, AC; Azevedo, A
Gender and obesity modify the impact of salt intake on blood pressure in children
Correia-Costa, L; Cosme, D; Nogueira-Silva, L; Morato, M; Sousa, T; Moura, C; Mota, C; Guerra, A; Albino-Teixeira, A; Areias, JC; Schaefer, F; Lopes, CBACKGROUND:Most modifiable risk factors for high blood pressure (BP), such as obesity and salt intake, are imprinted in childhood and persist into adulthood. The aim of our study was to evaluate the intake of salt in children and to assess its impact on BP taking into account gender and nutritional status. METHODS:A total of 298 children aged 8-9 years were evaluated in a cross-sectional study. Anthropometric m...
Normalization of glomerular filtration rate in obese children
Correia-Costa, L; Schaefer, F; Caldas-Afonso, A; Bustorff, M; Guimaraes, JT; Guerra, A; Barros, H; Azevedo, ABACKGROUND:Glomerular filtration rate (GFR) is conventionally indexed to body surface area (BSA), but this may lead to biased results when applied to subjects of abnormal body size. The aim of our study was to examine the impact of normalization to the BSA and alternative body size descriptors on measured and estimated GFR in overweight and obese children. METHODS:This was a cross-sectional study of 313 childre...
Decreased renal function in overweight and obese prepubertal children
Costa, L; Caldas-Afonso, A; Schaefer, F; Guimarães, JT; Bustorff, M; Guerra, A; Barros, H; Azevedo, ABACKGROUND: Obesity is a potentially modifiable risk factor for the development and progression of kidney disease, both in adults and children. We aim to study the association of obesity and renal function in children, by comparing estimated glomerular filtration rate (eGFR) in nonoverweight and overweight/obese children. Secondarily, we aim to evaluate the accuracy of equations on eGFR estimation when compared...