Exosomes are endosome-derived extracellular vesicles about 100 nm in diameter. They are emerging as prom ising delivery platforms due to their advantages in biocompatibility and engineerability. However, research into and applications for engineered exosomes are still limited to a few areas of medicine in mammals. Here, we expanded the scope of their applications to sex-determining gene studies in early vertebr...
Made available in DSpace on 2022-04-28T19:46:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; Julius-Maximilians-Universität Würzburg; Arapaima gigas is one of the largest freshwater fish species of high ecological and economic importance. Overfishing and habitat destruction are severe threats to the remaining wild populations. By incorporating a chromosomal Hi-C contact map, we improved the ara...
Competing endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and different...
Made available in DSpace on 2021-06-25T11:54:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-09; National Institute of Health (USA); Deutsche Forschungsgemeinschaft; National Science Foundation (USA) Office of Polar Programs; Agence Nationale de la Recherche; Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung; The study of sex determination and sex chromosome organization ...
Made available in DSpace on 2021-06-25T12:35:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-18; Deutsche Forschungsgemeinschaft; AquaCRISPR; TUNESAL (Research Project-HAVBRUK2); AQUAEXCEL 3.0 European Project; 111 Project (China); Graduate School of Life Sciences (GSLS); Sex determination (SD) is a highly diverse and complex mechanism. In vertebrates, one of the first morphological differences bet...
Made available in DSpace on 2019-10-06T15:38:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific adaptations and unique features of this iconic species, in particular it’s large size and fast g...
Allopolyploid plants are long known to be subject to a homoeolog expression bias of varying degree. The same phenomenon was only much later suspected to occur also in animals based on studies of single selected genes in an allopolyploid vertebrate, the Iberian fish Squalius alburnoides. Consequently, this species became a good model for understanding the evolution of gene expression regulation in polyploid vert...
Allopolyploid plants are long known to be subject to a homoeolog expression bias of varying degree. The same phenomenon was only much later suspected to occur also in animals based on studies of single selected genes in an allopolyploid vertebrate, the Iberian fish Squalius alburnoides. Consequently, this species became a good model for understanding the evolution of gene expression regulation in polyploid vert...
Flatfish have the most extreme asymmetric body morphology of vertebrates. During metamorphosis, one eye migrates to the contralateral side of the skull, and this migration is accompanied by extensive craniofacial transformations and simultaneous development of lopsided body pigmentation(1-5). The evolution of this developmental and physiological innovation remains enigmatic. Comparative genomics of two flatfish...
This article documents the public availability of (i) microbiomes in diet and gut of larvae from the dipteran Dilophus febrilis using massive parallel sequencing, (ii) SNP and SSR discovery and characterization in the transcriptome of the Atlantic mackerel (Scomber scombrus, L) and (iii) assembled transcriptome for an endangered, endemic Iberian cyprinid fish (Squalius pyrenaicus).