8 documents found, page 1 of 1
Partnership for productive development of biosimilar products: perspectives of ...
Scheinberg,Morton Aaron; Felix,Paulo Antonio Oldani; Kos,Igor Age; Andrade,Maurício De Angelo; Azevedo,Valderilio FeijóABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there ar...
Bone health in cerebral palsy and introduction of a novel therapy
Scheinberg,Morton Aaron; Golmia,Ricardo Prado; Sallum,Adriana Maluf Elias; Pippa,Maria Guadalupe Barbosa; Cortada,Aline Pinheiros dos SantosABSTRACT Objective To assess the bone health status of children with cerebral palsy and the therapeutic effect of denosumab in a subgroup of children with cerebral palsy and decreased bone mass. Methods Children with cerebral palsy were evaluated according to their motor disability score (classification system gross motor functions III to V), bone density and bone turnover markers. Dual X-ray energy absorption ...
Comparison of thromboprophylaxis patterns in arthroplasty in public and private...
Cortada,Aline Pinheiro dos Santos; Silva,Telma Gomes da; Silva,André Campos da; Golmia,Ricardo Prado; Guerra,Renata LeboratoObjective To compare therapy for prophylaxis of venous thromboembolism and costs related to hospitalization of patients undergoing total knee and hip replacement within the context of the Brazilian health system.Methods A retrospective study of patients undergoing arthroplasty in 2010 in a public hospital and two private hospitals in the state of São Paulo, conducted by means of medical record review. Costs wer...
Use of rituximab as a treatment for systemic lupus erythematosus: retrospective...
Machado,Roberta Ismael Lacerda; Scheinberg,Morton Aaron; Queiroz,Maria Yvone Carlos Formiga de; Brito,Danielle Christinne Soares Egypto deObjective : To report the experience in three Brazilian institutions with the use of rituximab in patients with different clinical forms of lupus erythematosus systemic in activity. Methods : The study consisted of a sample of 17 patients with LES, who were already being treated, but that at some stage of the disease showed refractory symptoms. The patients were subdivided into groups according to the clinical ...
Taxas de retenção de infliximabe e tocilizumabe no período de 3 anos em um hosp...
Golmia,Ricardo Prado; Scheinberg,Morton AaronOBJETIVO: Comparar a eficácia e período de uso de tocilizumabe e infliximabe no tratamento de pacientes com artrite reumatoide. MÉTODOS: Foi comparado o tempo de uso de dois biológicos com diferentes mecanismos de ação no tratamento de pacientes com artrite reumatoide. RESULTADOS: Ambos os biológicos se mostraram eficazes, mas o tempo de uso sem perda de eficácia foi maior com tocilizumabe quando comparado ao i...
Livedo reticular associado com Anemia Hemolítica Autoimune: remissão prolongada...
Ferreira,Eurípedes; Feitosa,Andrezza; Hamerschlak,Nelson; Scheinberg,Morton AaronA anemia hemolítica autoimune (AHAI) é uma doença na qual são produzidos anticorpos diretamente contra as glicoproteínas adsorvidas na superfície da membrana dos eritrócitos. Algumas medicações e outras associações têm sido implicadas. Descrevemos e discutimos um caso de livedo reticular associado à AHAI tratado com transplante de células-tronco de sangue periférico (TCTSP) e que entrou em total remissão por 10...
Diagnosis of growing pains in a Brazilian pediatric population: a prospective i...
Piano,Luciana Pereira Almeida de; Golmia,Ricardo Prado; Golmia,Andrea Pimentel Fonseca; Sallum,Adriana Maluf Elias; Nukumizu,Lucia AkemiABSTRACT Objective: To establish the clinical aspects of growing pains and to determine, through differential diagnosis, how many patients who referred themselves to a specialized clinic were found to have growing pains. Methods: This study prospectively examined the presence of growing pains in a self-reported population of children and adolescents with signs and symptoms (lower limb pains) of unexplained etio...
Amiloidose AL em um adulto jovem: remissão clínica e laboratorial com transplan...
Golmia,Ricardo Prado; Bello,Isabel Clapis; Rosseto,Eliane; Guerra,João Carlos Campos; Mangueira,Cristóvão; Scheinberg,Morton AaronTransplante autólogo de células tronco é uma das formas de tratamento da amiloidose primária ou AL. Os autores relatam um paciente de 46 anos com hematomas periorbitais bilaterais, macroglossia, em quem, na investigação, se constatou a presença de paraproteínas IgG Kappa no soro. O diagnóstico de amiloidose primária ou AL foi confirmado, e o tratamento proposto com condicionamento com doses altas de Melfalan, s...