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Justificativa e delineamento do estudo “Tocilizumabe em pacientes com COVID-19 ...
Farias,Danielle Leão Cordeiro de; Prats,João; Cavalcanti,Alexandre Biasi; Rosa,Regis Goulart; Machado,Flávia Ribeiro; Berwanger,OtávioRESUMO Introdução: Os marcadores pró-inflamatórios desempenham papel importante na severidade de pacientes com COVID-19. Assim, terapêuticas anti-inflamatórias são agentes interessantes para potencialmente combater a cascata inflamatória descontrolada em tais pacientes. Delineamos um ensaio para testar tocilizumabe em comparação com o tratamento padrão, tendo como objetivo melhorar os desfechos por meio da inib...
Outcome of children with severe acquired aplastic anemia treated with rabbit an...
Garanito,Marlene Pereira; Carneiro,Jorge David Aivazoglou; Odone Filho,Vicente; Scheinberg,PhillipObjective:To evaluate the outcome of children with severe acquired aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine as first-line treatment at this institution.Methods:Retrospective analysis of 26 pediatric patients with aplastic anemia, treated between 1996 and 2011 with rabbit antithymocyte globulin plus cyclosporine.Results:The overall response rate at six months was 34.6% (9/26), ...
Current management of severe acquired aplastic anemia
Scheinberg,PhillipOverall survival in severe aplastic anemia has markedly improved in the past four decades due to advances in stem cell transplantation, immunosuppressive therapies and supportive care. Horse anti-thymocyte globulin plus cyclosporine is the standard immunosuppressive regimen in severe aplastic anemia, and often employed as initial therapy as most are not candidates for a matched related stem cell transplantation...