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The NAD salvage pathway in mesenchymal cells is indispensable for skeletal deve...
Warren, Aaron; Porter, Ryan M; Reyes-Castro, Olivia; Ali, Md Mohsin; Carvalho, Adriana Marques; Kim, Ha-Neui; Gatrell, Landon B; Schipani, ErnestinaNAD is an essential co-factor for cellular energy metabolism and multiple other processes. Systemic NAD+ deficiency has been implicated in skeletal deformities during development in both humans and mice. NAD levels are maintained by multiple synthetic pathways but which ones are important in bone forming cells is unknown. Here, we generate mice with deletion of Nicotinamide Phosphoribosyltransferase (Nampt), a ...
Data: 2023
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Origem: Estudo Geral - Universidade de Coimbra