Background: Atovaquone/proguanil (AP) is a highly effective malaria chemoprophylaxis combination. According to current guidelines, AP is taken once daily during, and continued for seven days post exposure. A systematic review by Savelkoel et al. summarised data up to 2017 on abbreviated AP regimens, and concluded that discontinuing AP upon return may be effective, although the available data was insufficient to...
Fundaci?n Centro de Estudios Infectol?gicos. Buenos Aires, Argentina / Panel of Scientific Publications and Teaching, Latin American Society for Travel Medicine. Buenos Aires, Argentina.; Hospital General de Agudos P. Pi?ero. Buenos Aires, Argentina.; Latin American Society for Travel Medicine. Panel of Scientific Publications and Teaching. Buenos Aires, Argentina / Latin American Society for Travel Medicine. P...
It has been well documented that Zika virus (ZIKV) can be sexually transmitted. Dengue virus (DENV) shows many similarities with ZIKV; both belong to the genus Flavivirus and share the same main vector route of transmission. Moreover, they share overall architectural features on a molecular level, with a highly similar structure and distinctive insertions, deletions and mutations of their respective E proteins,...
Background: We evaluated existing data on the prophylactic efficacy of atovaquone-proguanil (AP) in order to determine whether prophylaxis in travellers can be discontinued on the day of return from a malaria-endemic area instead of seven days after return as per currently recommended post-travel schedule. Methods: PubMed and Embase databases were searched to identify relevant studies. This PROSPERO-registered ...