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Home- versus centre-based EXercise InTervention in patients with Heart Failure ...

Schmidt, Cristine; Magalhães, Sandra; Gois Basilio, Priscilla; Gouveia, Marisol; Teixeira, Manuel; Espírito Santo, Cláudio; Tavares, Aida Isabel

Introduction: The limited accessibility and the lack of adherence explain, in part, the low proportion of heart failure (HF) patients undergoing exercise-based cardiac rehabilitation (CR) programs. Home-based programs showed to be as effective and less costly than centre-based ones and might address those obstacles. Whether the evidence from international studies can be applied to our population is still unclea...


Exercise training decreases the load and changes the content of circulating SDS...

Gouveia, Marisol; Schmidt, Cristine; Basilio, Priscilla Gois; Aveiro, Susana; Domingues, Pedro; Xia, Ke; Colón, Wilfredo; Vitorino, Rui; Ferreira, Rita

BackgroundHeart failure (HF) often disrupts the protein quality control (PQC) system leading to protein aggregate accumulation. Evidence from tissue biopsies showed that exercise restores PQC system in HF; however, little is known about its effects on plasma proteostasis.AimTo determine the effects of exercise training on the load and composition of plasma SDS-resistant protein aggregates (SRA) in patients with...


PREOPERATIVE PHYSICAL ACTIVITY LEVELS AND POSTOPERATIVE BURDEN IN CANCER PATIEN...

Cardoso, Rodrigo; Guedes, Mariana; Pauli, Nicolle; Ehrenbrink, Gabriela; Poças, Keily; Castro, Carolina; Santos, Carla Salomé; Schmidt, Cristine

Introduction: There is a growing interest to understand the impact of preoperative physical activity (PA) levels in postoperative morbidity and mortality. The aim of this study is to assess the levels of PA in patients with head/neck or gastric cancer through accelerometry and compare postoperative burden among those “complying” or “not complying” with PA recommendations. Methods: We conducted an observational,...

Date: 2022   |   Origin: Revista Portuguesa de Cirurgia

Characterization of plasma SDS-protein aggregation profile of patients with hea...

Gouveia, Marisol; Schmidt, Cristine; Teixeira, Manuel; Lopes, Mário; Aveiro, Susana; Domingues, Pedro; Xia, Ke; Colón, Wilfredo; Vitorino, Rui

This study characterizes the plasma levels and composition of SDS-resistant aggregates (SRAs) in patients with heart failure with preserved ejection fraction (HFpEF) to infer molecular pathways associated with disease and/or proteostasis disruption. Twenty adults (ten with HFpEF and ten age-matched individuals) were included. Circulating SRAs were resolved by diagonal two-dimensional SDS-PAGE, and their protein...


Dynamic Balance and Mobility Explain Quality of Life in HFpEF, Outperforming Al...

Schmidt, Cristine; Santos, Mario; Bohn, Lucimere; Delgado, Bruno Miguel; Moreira-Gonçalves, Daniel; Leite-Moreira, Adelino; Oliveira, José

Background Physical fitness is an important determinant of quality of life (QoL) in heart failure with preserved ejection fraction (HFpEF) patients. However, how the different physical fitness components correlate with the specific dimensions of QoL in HFpEF patients remains unknown. Objective To evaluate the association between different physical fitness components and QoL dimensions in HFpEF patients, and, as...


Cardiac rehabilitation programs for heart failure patients in the time of COVID-19

Schmidt, Cristine; Magalhães, Sandra; Barreira, Ana; Ribeiro, Fernando; Fernandes, Preza; Santos, Mario


Exercise preconditioning prevents left ventricular dysfunction and remodeling i...

Schmidt, Cristine; Bovolini, José A.; Gonçalves, Nádia; Vasques-Nóvoa, Francisco; Andrade, Maria do Amparo; Santos, Mário; Leite-Moreira, Adelino

Background: Despite pulmonary arterial hypertension (PAH) directly affects the right ventricle (RV), important structural, functional, and molecular changes also occur in left ventricle (LV). The objective of our study was to analyze the hypothetical cardioprotective effects of exercise preconditioning on LV in rats with monocrotaline (MCT)-induced PAH. Methods: Forty male Wistar rats were randomly separated in...


Comparison of questionnaire and accelerometer-based assessments of physical act...

Schmidt, Cristine; Santos, Mario; Bohn, Lucimere; Delgado, Bruno Miguel; Moreira-Gonçalves, Daniel; Leite-Moreira, Adelino; Oliveira, José

Objective. (i) To compare daily physical activity (PA) levels evaluated by the International Physical Activity Questionnaire (IPAQ) and by triaxial accelerometry in heart failure with preserved ejection fraction (HFpEF) patients; (ii) to describe daily PA patterns based in objective measurements; and (iii) to observe the association between prognostic indicators and PA measurements. Design. This is a cross-sect...


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