43 documents found, page 1 of 5
Invisible for a few but essential for many: the role of Histotechnologists in t...
Magalhães, Gisela; Calisto, Rita; Freire, Catarina; Silva, Regina; Montezuma, Diana; Canberkg, Sule; Schmitt, FernandoDigital pathology (DP) is indisputably the future for histopathology laboratories. The process of digital implementation requires deep workflow reorganisation which involves an interdisciplinary team. This transformation may have the greatest impact on the Histotechnologist (HTL) profession. Our review of the literature has clearly revealed that the role of HTLs in the establishment of DP is being unnoticed and...
Investigator-Led Clinical Research in Portugal: Problem Identification and Prop...
Ferreira, João Pedro; Leite-Moreira, Adelino; da Costa-Pereira, Altamiro; Soares, António José; Robalo-Cordeiro, Carlos; Jerónimo, CármenN/a.; N/a.
Investigação clínica da iniciativa do investigador em Portugal: identificação d...
Ferreira, João Pedro; Leite-Moreira, Adelino; Da Costa-Pereira, Altamiro; Soares, António José; Robalo-Cordeiro, Carlos; Jerónimo, CármenPortugal tem um problema crónico de subfinanciamento da investigação científica. Apesar do investimento nacional ter vindo a aumentar nos últimos anos, este ainda é manifestamente insuficiente. A Fundação para a Ciência e Tecnologia (FCT) financia anualmente projetos de investigação em todas as áreas científicas, limitando o valor máximo a €250 000 por projeto. Todavia, a área científica na qual a investigação ...
Investigação clínica da iniciativa do investigador em Portugal: identificação d...
Ferreira, João Pedro; Leite-Moreira, Adelino; Da Costa-Pereira, Altamiro; Soares, António José; Robalo-Cordeiro, Carlos; Jerónimo, CármenPortugal tem um problema cronico de subfinanciamento da investigacao cientifica. Apesar do investimento nacional ter vindo a aumentar nos ultimos anos, este ainda e manifestamente insuficiente.1 A Fundacao para a Ciencia e Tecnologia (FCT) financia anualmente projetos de investigacao em todas as areas cientificas, limitando o valor maximo a euro250 000 por projeto. Todavia, a area cientifica na qual a investiga...
New Quantum-Dot-Based Fluorescent Immunosensor for Cancer Biomarker Detection
Sousa, Mariana P.; Piloto, Ana Margarida L.; Pereira, Ana Cláudia; Schmitt, Fernando; Fernandes, Ruben; Moreira, Felismina T. C.Cancer antigen 15-3 (CA 15-3) is a biomarker for breast cancer used to monitor response to treatments and disease recurrence. The present work demonstrates the preparation and application of a fluorescent biosensor for ultrasensitive detection of the cancer antigen CA 15-3 protein tumor marker using mercaptopropionic-acid-functionalized cadmium telluride (CdTe@MPA) quantum dots (QDs) conjugated with CA 15-3 ant...
Performance of the Bethesda system for reporting thyroid cytology in multi-inst...
Canberk, Sule; Barroca, Helena; Girão, Inês; Aydın, Ozlem; Uguz, Aysun; Erdogan, Kıvılcım; Tastekin, Ebru; Bongiovanni, Massimo; Soares, PaulaBackground: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted in 4 institutions to identify consecutive thyroid FNAC cases in paediatric population between 2000 and 2018. Following the 2nd TBSRTC, the risk o...
Disruption of pH dynamics suppresses proliferation and potentiates doxorubicin ...
Tavares-Valente, Diana; Sousa, Bárbara; Schmitt, Fernando; Baltazar, Fátima; Queirós, OdíliaThe reverse pH gradient is a major feature associated with cancer cell reprogrammed metabolism. This phenotype is supported by increased activity of pH regulators like ATPases, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs) and sodium–proton exchangers (NHEs) that induce an acidic tumor microenvironment, responsible for the cancer acid-resistant phenotype. In this work, we analyzed the expressio...
P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by...
Sousa, Bárbara; Pereira, Joana; Marques, Ricardo; Grilo, Luís F; Pereira, Susana P; Oliveira, Vilma Marisa Arrojado Soares Sardão; Schmitt, FernandoSuccessful metastatic spreading relies on cancer cells with stem-like properties, glycolytic metabolism and increased antioxidant protection, allowing them to escape anoikis and to survive in circulation. The expression of P-cadherin, a poor prognostic factor in breast cancer, is associated with hypoxic, glycolytic and acidosis biomarkers. In agreement, P-cadherin-enriched breast cancer cell populations present...
Disruption of E-Cadherin Pattern in Uterine and Mammary Tumours
Gama, Adelina; Seixas, Fernanda; Pires, Maria dos Anjos; Schmitt, Fernando; Payan-Carreira, RitaE-cadherin (E-cadh), a member of the classic cadherins superfamily, plays an important role in epithelial cell-to-cell adhesion, encompassing the dynamic interactions between adjacent cells including the control of morphogenesis, maintenance of cell polarity and tissue architecture. Cadherins comprise a large family of cell surface glycoproteins, presenting unique extracellular regions domains known as the cadh...
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma ...
Afonso, Julieta Alexandra Pereira; Pinto, Tatiana; Sousa, Susana Patrícia Simões; Schmitt, Fernando; Longatto, Adhemar; Pinheiro, CélineIncreased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glyco...