17 documents found, page 1 of 2
Microcarrier-based fluorescent yeast estrogen screen assay for fast determinati...
Gregório, Bruno J.R.; Ramos, Inês I.; Marques, Sara S.; Barreiros, Luísa; Magalhães, Luís M.; Schneider, Rudolf J.; Segundo, Marcela A.The presence of endocrine-disrupting compounds (EDCs) in water poses a significant threat to human and animal health, as recognized by regulatory agencies throughout the world. The Yeast Estrogen Screen (YES) assay is an excellent method to evaluate the presence of these compounds in water due to its simplicity and capacity to assess the bioaccessible forms/fractions of these compounds. In the presence of a com...
Salinity-dependent impacts on the effects of antiepileptic and antihistaminic d...
Almeida, Ângela; Calisto, Vânia; Esteves, Valdemar I.; Schneider, Rudolf J.; Soares, Amadeu M. V. M.; Freitas, RosaIn coastal systems, pollutants as pharmaceutical drugs exert changes from the molecular to the organism level in marine bivalves. Besides pollutants, coastal systems are prone to changes in environmental parameters, as the alteration of salinity values because of Climate Change. Together, these stressors (pharmaceutical drugs and salinity changes) can exert different threats than each stressor acting individual...
Can ocean warming alter sub-lethal effects of antiepileptic and antihistaminic ...
Almeida, Ângela; Calisto, Vânia; Esteves, Valdemar I.; Schneider, Rudolf J.; Figueira, Etelvina; Soares, Amadeu M. V. M.; Freitas, RosaThe negative effects induced in marine organisms by Climate Change related abiotic factors consequences, namely ocean warming, are well-known. However, few works studied the combined impacts of ocean warming and contaminants, as pharmaceutical drugs. Carbamazepine (CBZ) and cetirizine (CTZ) occur in the marine environment, showing negative effects in marine organisms. This study aimed to evaluate the impacts of...
ELISA as an effective tool to determine spatial and seasonal occurrence of emer...
Silva, Carla Patrícia; Carvalho, Tânia; Schneider, Rudolf J.; Esteves, Valdemar I.; Lima, Diana L. D.During the last two decades, studies related to the occurrence and fate of emerging contaminants in the aquatic environment have received great attention from the international scientific community. The presence of these compounds is particularly important since they are known to induce adverse effects in aquatic environments, even at extremely low concentrations. This work aimed to apply a simple and effective...
Effects of single and combined exposure of pharmaceutical drugs (carbamazepine ...
Almeida, Ângela; Calisto, Vânia; Esteves, Valdemar I.; Schneider, Rudolf J.; Soares, Amadeu M. V. M.; Figueira, Etelvina; Freitas, RosaIn the aquatic environment, organisms are exposed to complex mixtures of contaminants which may alter the toxicity profile of each compound, compared to its toxicity alone. Pharmaceutical drugs (e.g. carbamazepine (CBZ) and cetirizine (CTZ)) and metals (e.g. cadmium (Cd)) are among those contaminants that co-occur in the environment. However, most studies concerning their toxicity towards aquatic species are ba...
Effects of carbamazepine and cetirizine under an ocean acidification scenario o...
Almeida, Ângela; Freitas, Rosa; Calisto, Vânia; Esteves, Valdemar I.; Schneider, Rudolf J.; Soares, Amadeu M. V. M.; Figueira, Etelvina; Campos, BrunoSeveral works evaluated the toxicity of pharmaceutical drugs and climate related changes in invertebrates but few explored the combined effects of both stressors, namely considering their mode of action (MoA). Carbamazepine (CBZ) and cetirizine (CTZ) are pharmaceutical drugs detected in the environment and the toxicity derived from the combined effects of these drugs with ocean acidification (OA) is poorly expl...
Effects of single and combined exposure effects of pharmaceutical drugs (carbama...
Almeida, Ângela; Calisto, Vânia; Esteves, Valdemar I.; Schneider, Rudolf J.; Soares, Amadeu M. V. M.; Figueira, Etelvina; Freitas, RosaIn the aquatic environment, organisms are exposed to complex mixtures of contaminants which may alter the toxicity profile of each compound, compared to its toxicity alone. Pharmaceutical drugs (e.g. carbamazepine (CBZ) and cetirizine (CTZ)) and metals (e.g. cadmium (Cd)) are among those contaminants that co-occur in the environment. However, most studies concerning their toxicity towards aquatic species are ba...
Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic ...
Korsak, Barbara; Almeida, Gabriela M.; Rocha, Sara; Pereira, Carla; Mendes, Nuno; Osório, Hugo; Pereira, Patrícia M. R.; Rodrigues, João M. M.Gastric cancer (GC) is the 3rd deadliest cancer worldwide, due to limited treatment options and late diagnosis. Human epidermal growth factor receptor-2 (HER2) is overexpressed in ∼20% of GC cases and anti-HER2 antibody trastuzumab in combination with conventional chemotherapy, is recognized as standard therapy for HER2-positive metastatic GC. This strategy improves GC patients' survival by 2-3 months, however ...
How life history influences the responses of the clam Scrobicularia plana to th...
Freitas, Rosa; Almeida, Ângela; Calisto, Vânia; Velez, Cátia; Moreira, Anthony; Schneider, Rudolf J.; Esteves, Valdemar I.; Wrona, Frederick J.In the present study, the bivalve Scrobicularia plana, collected from two contrasting areas (pristine location and mercury contaminated area), was selected to assess the biochemical alterations imposed by pH decrease, carbamazepine (an antiepileptic) and the combined effect of both stressors. The effects on oxidative stress related biomarkers after 96 h exposure revealed that pH decrease and carbamazepine induc...
The effects of carbamazepine on macroinvertebrate species: comparing bivalves a...
Freitas, Rosa; Almeida, Ângela; Pires, Adília; Velez, Cátia; Calisto, Vânia; Schneider, Rudolf J.; Esteves, Valdemar I.; Wrona, Frederick J.In the present study, the bivalve Scrobicularia plana and the polychaete Diopatra neapolitana were exposed to an increasing carbamazepine (CBZ) concentration gradient. Both species are among the most widely used bioindicators, and CBZ is one of the most commonly found drugs in the aquatic environment. After a chronic exposure (28 days), the results obtained revealed that CBZ induced biochemical alterations in b...