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D-PRISM

Reyes, Luis Felipe; Serrano-Mayorga, Cristian C.; Zhang, Zhongheng; Tsuji, Isabela; De Pascale, Gennaro; Prieto, Valeria Enciso; Mer, Mervyn

Publisher Copyright: © The Author(s) 2024.; Background: Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite the availability of international guidelines, there remains heterogeneity in clinical management. The D-PRISM study aimed to develop a global overview of how pneumonias (i.e., community-acquired (CAP), hospital-acqui...


When to Stop Antibiotics in the Critically Ill?

Nielsen, Nathan D.; Dean, James T.; Shald, Elizabeth A.; Conway Morris, Andrew; Povoa, Pedro; Schouten, Jeroen; Parchim, Nicholas

Publisher Copyright: © 2024 by the authors.; Over the past century, antibiotic usage has skyrocketed in the treatment of critically ill patients. There have been increasing calls to establish guidelines for appropriate treatment and durations of antibiosis. Antibiotic treatment, even when appropriately tailored to the patient and infection, is not without cost. Short term risks—hepatic/renal dysfunction, interm...


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