4 documents found, page 1 of 1
Polymorphisms within autophagy-related genes as susceptibility biomarkers for m...
Clavero, Esther; Sanchez-Maldonado, José Manuel; Macauda, Angelica; Ter Horst, Rob; Marques, Maria Belém Sousa Sampaio; Jurczyszyn, ArturMultiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promot...
Identification of miRSNPs associated with the risk of multiple myeloma
Macauda, Angelica; Calvetti, Diego; Maccari, Giuseppe; Hemminki, Kari; Försti, Asta; Goldschmidt, Hartmut; Weinhold, Niels; Houlston, RichardMultiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest that genetic factors are involved in MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) associated with the susceptibility ...
A common variant within the HNF1B gene is associated with overall survival of m...
Ríos-Tamayo, Rafael; Lupiañez, Carmen Belén; Campa, Daniele; Hielscher, Thomas; Weinhold, Niels; Martínez-López, Joaquin; Jerez, Andrés; Landi, StefanoDiabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rE...
Comprehensive investigation of genetic variation in the 8q24 region and multipl...
Reis, R. M.; Campa, Danielr; Martino, Alessandro; Sainz, Juan; Buda, Gabriele; Jamroziak, Krzysztof; Weinhold, Niels; García-Sanz, Ramón; Jurado, ManuelGenome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 c...