Publisher Copyright: Copyright © 2025 Tripepi, da Costa, Albergaria, Costa, Catarino, Duarte, Bartosch, Schuler, Oliveira, Lima and Casanova.; Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare, highly aggressive malignancy that predominantly affects young women. We report a 32-year-old pregnant woman diagnosed with SCCOHT during the first trimester of pregnancy. At 24 weeks, imaging reve...