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Choroidal Binarization Analysis: Clinical Application
Crisóstomo, S; Cardigos, J; Hipólito Fernandes, D; Luís, ME; Figueiredo, R; Moura-Coelho, N; Cunha, JP; Abegão Pinto, L; Tavares-Ferreira, JIntroduction: Image processing of optical coherence tomography scans through binarization techniques represent a non-invasive way to separately asses and measure choroidal components, in vivo. In this review, we systematically search the scientific literature regarding binarization studies published so far. Methods: A systematic research was conducted at PubMed database, including English literature articles fo...
Nanotechnology-Ocular Devices for Glaucoma Treatment: A Literature Review
Cardigos, J; Ferreira, Q; Crisóstomo, S; Coelho, N; Cunha, JP; Abegão Pinto, L; Ferreira, JNanotechnology enabled the development of materials and devices with great utility in different fields of medicine. By using engineered-based nano-devices and structures, human biological systems may be controlled and repaired at a molecular scale, ultimately leading to a biological benefit. In particular, in the field of glaucoma treatment, nanotechnology may, for example, enhance drug residence time on the oc...
Retina and Choroid of Diabetic Patients Without Observed Retinal Vascular Chang...
Ferreira, J; Proença, R; Alves, M; Dias-Santos, A; Santos, B; Cunha, JP; Papoila, AL; Abegão Pinto, LPURPOSE: To identify changes in choroidal thickness (CT) and all retinal layers of diabetic patients without diabetic retinopathy (DR) after 1 year of follow-up. DESIGN: Prospective observational cohort study. METHODS: Overall, 125 diabetic patients without DR were included. Two visits were scheduled: the first visit (V1) and a second visit after 12 months (V2). At both visits, patients received a complete opht...
Diabetic Choroidopathy: a Review of the Current Literature
Melancia, D; Vicente, A; Cunha, JP; Abegão Pinto, L; Ferreira, JDiabetic retinopathy is an increasingly prevalent disease, and a leading contributor to the burden of all-cause blindness worldwide. In addition to retinal changes, choroidal abnormalities are common in patients with diabetes. The first studies concerning this vascular structure were based on histologic, indocyanine angiography and laser Doppler flowmetry techniques, but the development of new optical coherence...
Secondary Epiretinal Membrane After Trabeculectomy
Vieira, L; Cabugueira, A; Borges, B; Carvalho, V; Noronha, M; Abegão Pinto, L; Reina, M; Dutra Medeiros, MPurpose: To determine the frequency of epiretinal membranes (ERM) in eyes with primary open-angle glaucoma subjected to trabeculectomy. Methods: We conducted a retrospective study on patients subjected to trabeculectomy with at least a 6-month follow-up. Ophthalmologic examination and spectral-domain optical coherence tomography (SD-OCT) were analyzed. Eyes with previous surgical or laser treatments or other pa...
Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy
Tavares Ferreira, J; Alves, M; Dias-Santos, A; Costa, L; Santos, B; Cunha, JP; Papoila, AL; Abegão Pinto, LPURPOSE: To compare the thickness of all retinal layers between a nondiabetic group and diabetic patients without diabetic retinopathy (DR). METHODS: Cross-sectional study, in which all subjects underwent an ophthalmic examination including optical coherence tomography. After automatic retinal segmentation, each retinal layer thickness (eight separate layers and overall thickness) was calculated in all nine Ear...
Phacoemulsification Versus Peripheral Iridotomy in the Management of Chronic Pr...
Dias-Santos, A; Ferreira, J; Abegão Pinto, L; Domingues, I; Silva, JP; Cunha, JP; Reina, MPrimary angle closure occurs as a result of crowded anterior segment anatomy, causing appositional contact between the peripheral iris and trabecular meshwork, thereby obstructing aqueous outflow. Several studies highlight the role of the crystalline lens in its pathogenesis. The objective of this work is to compare the long-term efficacy of phacoemulsification versus laser peripheral iridotomy (LPI) in the man...
Diabetes Mellitus as a Risk Factor in Glaucoma's Physiopathology and Surgical S...
Costa, L; Cunha, JP; Amado, D; Abegão Pinto, L; Ferreira, JGlaucoma is a multifactorial condition under serious influence of many risk factors. The role of diabetes mellitus (DM) in glaucoma etiology or progression remains inconclusive. Although, the diabetic patients have different healing mechanism comparing to the general population and it has a possible-negative role on surgical outcomes. This review article attempts to analyze the association of both diseases, gla...
Intraocular Pressure in Eyes Receiving Intravitreal Antivascular Endothelial Gr...
Lemos, V; Cabugueira, A; Noronha, M; Abegão Pinto, L; Reina, M; Branco, J; Gomes, TPURPOSE: The aim of the this study was to determine the effect of intravitreal antivascular endothelial growth factor injections on intraocular pressure (IOP) and identify possible risk factors for the development of increased IOP. MATERIALS AND METHODS: This prospective study included a total of 106 eyes receiving intravitreal injection of bevacizumab as treatment for macular edema or active choroidal neovascu...
Intracameral Bevacizumab as an Adjunct to Trabeculectomy: a 1-Year Prospective,...
Vandewalle, E; Abegão Pinto, L; Bergen, T; Spielberg, L; Fieuws, S; Moons, L; Spileers, W; Zeyen, T; Stalmans, IAims: To investigate the efficacy and safety of a single intracameral bevacizumab injection to improve the outcome of trabeculectomy. Methods: A 12-month, prospective, randomised, double-masked, placebo-controlled trial. Patients with medically uncontrolled open-angle glaucoma scheduled for a primary trabeculectomy were recruited and randomised to receive 50 µL of either bevacizumab (1.25 mg) or placebo (balanc...