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Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) co...
Ribeiro, Nádia; Bulut, Ipek; Sergi, Baris; Pósa, Vivien; Spengler, Gabriella; Sciortino, Giuseppe; André, Vânia; Ferreira, Liliana P.; Biver, TaritaWe report the synthesis and characterization of a group of benzoylhydrazones (Ln) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH3, OCH3, OH and NH2, for L1-7, respectively; in L8 isonicotinohydrazide was used instead of benzylhydrazide). Cu(II) complexes were prepared by reaction of each benzoylhydrazone with Cu(II) acetate. All compou...
Polyoxidovanadates' interactions with proteins: an overview
Aureliano, Manuel; Gumerova, Nadiia I.; Sciortino, Giuseppe; Garribba, Eugenio; McLauchlan, Craig C.; Rompel, Annette; Crans, Debbie C.Polyoxidovanadates (POVs, previously named polyoxovanadates) are a subgroup of polyoxidometalates (POMs, previously named polyoxometalates) with interesting pharmacological actions that have been tested as potential antidiabetic, antibacterial, antiprotozoal, antiviral, and anticancer drugs. They contain mainly vanadium and are able to interact with proteins, affecting various biological processes. The most stu...
Polyoxovanadates with emerging biomedical activities
Aureliano, Manuel; Gumerova, Nadiia I.; Sciortino, Giuseppe; Garribba, Eugenio; Rompel, Annette; Crans, Debbie C.Polyoxovanadates (POVs) are a subclass of a larger family of polyanionic group V and VI metal-oxo clus ters that are known as polyoxometalates (POMs). POMs have been found to have antidiabetic, antibacte rial, antiprotozoal, antiviral and anticancer activities, which have sparked interest in their use as bioinorganic drugs. Among POVs, decavanadate ([V10O28] 6 ; V10) is an isopolyoxovanadate recently described ...