6 documents found, page 1 of 1
Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines
Borges,Kleiton Silva; Brassesco,María Sol; Scrideli,Carlos Alberto; Soares,Ademilson Espencer Egea; Tone,Luiz GonzagaPropolis is a resin formed by a complex chemical composition of substances that bees collect from plants. Since ancient times, propolis has been used in folk medicine, due to its biological properties, that include antimicrobial, anti-inflammatory, antitumoral and immunomodulatory activities. Glioblastoma is the most common human brain tumor. Despite the improvements in GBM standard treatment, patients' prognos...
Moyamoya syndrome associated with neurofibromatosis type I in a pediatric patient
Darrigo Júnior,Luiz Guilherme; Valera,Elvis Terci; Machado,André de Aboim; Santos,Antonio Carlos dos; Scrideli,Carlos Alberto; Tone,Luiz GonzagaCONTEXT: Neurofibromatosis type 1 (NF-1) is the most prevalent autosomal dominant genetic disorder among humans. Moyamoya disease is a cerebral vasculopathy that is only rarely observed in association with NF-1, particularly in the pediatric age range. The present study reports an occurrence of this association in an infant. CASE REPORT: An eight-month-old female presented convulsive seizures with clonic moveme...
Multiple drug resistance protein (MDR-1), multidrug resistance-related protein ...
Valera,Elvis Terci; Scrideli,Carlos Alberto; Queiroz,Rosane Gomes de Paula; Mori,Bianca Maria Ortelli; Tone,Luiz GonzagaCONTEXT: Despite the advances in the cure rate for acute lymphoblastic leukemia, approximately 25% of affected children suffer relapses. Expression of genes for the multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP), and lung resistance protein (LRP) may confer the phenotype of resistance to the treatment of neoplasias. OBJECTIVE: To analyze the expression of the MDR-1, MRP and...
Analysis of p16 gene mutations and deletions in childhood acute lymphoblastic l...
Lemos,José Alexandre Rodrigues; Defavery,Ricardo; Scrideli,Carlos Alberto; Tone,Luiz GonzagaCONTEXT: The p16 tumor suppressor gene encodes a cyclin-dependent kinase 4 inhibitor that blocks cell division during the G1 phase of the cell cycle. Alterations in this gene have been reported for various neoplasia types, including acute lymphoblastic leukemias (ALL), especially T-cell acute lymphoblastic leukemias (ALL). OBJECTIVE: To determine probable alterations in the p16 gene in children with acute lymph...
Inactivation of the p15 gene in children with acute lymphoblastic leukemia
Cipolotti,Rosana; Lemos,José Alexandre Rodrigues; Defavery,Ricardo; Scrideli,Carlos Alberto; Dal Fabbro,Amaury Lellis; Tone,Luiz GonzagaCONTEXT: Tumor suppressor genes act on the control of cell cycle progression. In pediatric neoplasias, some of these genes may be considered to be markers for diagnosis or relapse, thus probably representing prognostic indicators. OBJECTIVE: To study the inactivation of the p15 gene in children with acute lymphoblastic leukemia. TYPE OF STUDY: Retrospective study. SETTING: Laboratory of Molecular Biology, Depar...
Prognostic significance of bi/oligoclonality in childhood acute lymphoblastic l...
Scrideli,Carlos Alberto; Defavery,Ricardo; Bernardes,José Eduardo; Tone,Luíz GonzagaCONTEXT: The CDR-3 region of heavy-chain immunoglobulin has been used as a clonal marker in the study of minimal residual disease in children with acute lymphoblastic leukemia. Southern blot and polymerase chain reaction studies have demonstrated the occurrence of bi/oligoclonality in a variable number of cases of B-lineage acute lymphoblastic leukemia, a fact that may strongly interfere with the detection of m...