3 documents found, page 1 of 1
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology a...
Socodato, R; Portugal, CC; Canedo, T; Rodrigues, A; Almeida, TO; Henriques, JF; Vaz, SH; Magalhães, J; Silva, CM; Baptista, FI; Alves, RLNervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in adult microglia is sufficient to trigger spontaneous microglia activation, producing a neurological phenotype (including synapse and neuron loss, impairment of long-term potentiation [LTP], formation of ß-amyloid plaques, and memory ...
Impairment of Adenosinergic System in Rett syndrome: Novel Therapeutic Target t...
Miranda-Lourenço, C; Duarte, ST; Palminha, C; Gaspar, C; Rodrigues, TM; Magalhães-Cardoso, T; Rei, N; Colino-Oliveira, M; Gomes, R; Ferreira, S; Rosa, JRett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to impairments in the brain-derived neurotrophic factor (BDNF) signalling. The boost of BDNF mediated effects would be a significant breakthrough but it has been hampered by the difficulty to administer BDNF to the central nervous system. Adenosine, an endogenou...
Modeling Rett Syndrome With Human Patient-Specific Forebrain Organoids
Gomes, AR; Fernandes, TG; Vaz, SH; Silva, TP; Bekman, EP; Xapelli, S; Duarte, S; Ghazvini, M; Gribnau, J; Muotri, AR; Trujillo, CA; Sebastião, AMEngineering brain organoids from human induced pluripotent stem cells (hiPSCs) is a powerful tool for modeling brain development and neurological disorders. Rett syndrome (RTT), a rare neurodevelopmental disorder, can greatly benefit from this technology, since it affects multiple neuronal subtypes in forebrain sub-regions. We have established dorsal and ventral forebrain organoids from control and RTT patient-...