2 documents found, page 1 of 1
Low doses of ionizing radiation activate endothelial cells and induce angiogene...
Gil Marques, Filipa; Poli, Maria Esmeralda; Malaquias, João; Carvalho, Tânia; Portêlo, Ana; Ramires, Afonso; Aldeia, Fernando; Ribeiro, Ruy M.Purpose: During radiotherapy the peritumoral tissues are daily exposed to subtherapeutic doses of ionizing radiation. Herein, the biological and molecular effects of doses lower than 0.8 Gy per fraction (LDIR), previously described as angiogenesis inducers, were assessed in human peritumoral tissues. Material and methods: Paired biopsies of preperitoneal adipose tissue were surgically collected from 16 patients...
Low-dose ionizing radiation induces therapeutic neovascularization in a pre-cli...
Ministro, Augusto; Oliveira, Paula de; Nunes, Raquel J.; Rocha, André dos Santos; Correia, Adriana; Carvalho, Tânia; Rino, José; Faísca, PedroAims: We have previously shown that low-dose ionizing radiation (LDIR) induces angiogenesis but there is no evidence that it induces neovascularization in the setting of peripheral arterial disease. Here, we investigated the use of LDIR as an innovative and non-invasive strategy to stimulate therapeutic neovascularization using a model of experimentally induced hindlimb ischemia (HLI). Methods and results: Afte...