2 documents found, page 1 of 1
Early programming of the oocyte epigenome temporally controls late prophase I t...
Navarro-Costa, Paulo; McCarthy, Alicia; Prudêncio, Pedro; Greer, Christina; Guilgur, Leonardo G.; Becker, Jörg D.; Secombe, Julie; Rangan, PrashanthOocytes are arrested for long periods of time in the prophase of the first meiotic division (prophase I). As chromosome condensation poses significant constraints to gene expression, the mechanisms regulating transcriptional activity in the prophase I-arrested oocyte are still not entirely understood. We hypothesized that gene expression during the prophase I arrest is primarily epigenetically regulated. Here w...
Early programming of the oocyte epigenome temporally controls late prophase I t...
Navarro-Costa, Paulo; McCarthy, Alicia; Prudencio, Pedro; Greer, Christina; Guilgur, Leonardo Gastón; Becker, Jorg D.; Secombe, Julie; Rangan, PrashanthOocytes are arrested for long periods of time in the prophase of the first meiotic division (prophase I). As chromosome condensation poses significant constraints to gene expression, the mechanisms regulating transcriptional activity in the prophase I-arrested oocyte are still not entirely understood. We hypothesized that gene expression during the prophase I arrest is primarily epigenetically regulated. Here w...